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DNA methylation patterns in twins discordant for ALS reveal concordant signatures of disease

ABSTRACT: DNA methylation patterns in twins discordant for ALS reveal concordant signatures of disease

PROVIDER: PRJNA352274 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR4842490.fastq.gz	Fastqsanger.gz
	SRR4842491.fastq.gz	Fastqsanger.gz
	SRR4842492.fastq.gz	Fastqsanger.gz
	SRR4842483.fastq.gz	Fastqsanger.gz
	SRR4842484.fastq.gz	Fastqsanger.gz

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Project description:The exploration of copy number variation (CNV), notably of somatic cells, is an understudied aspect of genome biology. Any differences in the genetic make-up between twins derived from the same zygote represent an extreme example of somatic variation. We studied 19 pairs of monozygotic twins with either concordant or discordant phenotype using two platforms for genome-wide CNV analyses and show that CNVs exist within pairs in both groups. These findings impact our views of genotypic and phenotypic diversity in monozygotic twins, and suggest that CNV analysis in phenotypically discordant monozygotic twins may provide a powerful tool in identifying disease predisposition loci. Our results also imply that caution should be exercised with the interpretation of disease causality of de novo CNVs found in patients based on analysis of a single tissue in routine disease-related DNA diagnostics Analysis of copy number variability in concordant healthy monozygotic twin pairs as well as three monozygostic twin pairs discordant a Parkinsons disease (PD) phenotype using the Illumina HumanHap 300 dead chips. Genotyping using the HumanHap300-duo bead chip from Illumina, GEO accession GPL5711

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DNA methylation patterns in twins discordant for ALS reveal concordant signatures of disease

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