Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mannheimia haemolytica

ABSTRACT: Causes respiratory disease in cattle

PROVIDER: PRJNA35253 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	AASA01.dat.gz	Other
	AASA01.fasta.gz	Fasta.gz
	AASA01.master.dat	Other
	ACZX01.dat.gz	Other

Items per page:

1 - 5 of 3927

Similar Datasets

Mannheimia haemolytica PHL213

Project description:Causes major respiratory disease in cattle

| PRJNA221 | ENA

Mannheimia haemolytica

Project description:Raw Sequence Reads of Mannheimia haemolytica Isolates From Cattle

| PRJNA326933 | ENA

Proteomic analysis and immunogenicity of Mannheimia haemolytica vesicles.

Project description:Mannheimia haemolytica, a major causative agent in bovine respiratory disease, inflicts extensive losses each year on cattle producers. Commercially available vaccines are only partially efficacious. Immunity to M. haemolytica requires antibodies to secreted toxins and outer membrane proteins (OMPs) of the bacterium. Gram-negative bacteria produce membrane blebs or vesicles, the membrane components of which are primarily derived from OMPs. Accordingly, vesicles have been used as immunogens with various degrees of success. This study characterized components of M. haemolytica vesicles and determined their immunogenicity in mice and cattle. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of vesicles from this bacterium identified 226 proteins, of which 58 (25.6%) were OMPs and periplasmic and one (0.44%) was extracellular. Vesicles were used to vaccinate dairy calves and BALB/c mice. Analyses of sera from calves and mice by enzyme-linked immunosorbent assay (ELISA) showed that circulating antibodies against M. haemolytica whole cells and leukotoxin were significantly higher on days 21 and 28 (P < 0.05) than on day 0. For control calves and mice, there were no significant differences in serum anti-whole-cell and leukotoxin antibody levels from days 0 and 21 or 28, respectively. Lesion scores of lungs from vaccinated calves (15.95%) were significantly (P < 0.05) lower than those from nonvaccinated calves (42.65%). Sera from mice on day 28 and calves on day 21 showed 100% serum bactericidal activity. Sera from vesicle-vaccinated mice neutralized leukotoxin.

| S-EPMC3571273 | biostudies-literature

Mannheimia haemolytica

Project description:Identification of genetic markers of resistance to macrolide class antibiotics in Mannheimia haemolytica

| PRJNA1088094 | ENA

Mannheimia haemolytica

Project description:Mannheimia haemolytica Genome sequencing and assembly

| PRJNA1060525 | ENA

Mannheimia haemolytica

Project description:Mannheimia haemolytica Genome sequencing and assembly

| PRJNA181191 | ENA

Mannheimia haemolytica

Project description:Mannheimia haemolytica Genome sequencing