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Staphylococcus aureus subsp. aureus USA300

ABSTRACT: Changes in relative transcript amounts caused by ∆ftsH in Staphylococcus aureus USA300

PROVIDER: PRJNA353307 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5014660.fastq.gz	Fastqsanger.gz
	SRR5014661.fastq.gz	Fastqsanger.gz
	SRR5014662.fastq.gz	Fastqsanger.gz
	SRR5014663.fastq.gz	Fastqsanger.gz
	SRR5014664.fastq.gz	Fastqsanger.gz

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Expression analysis of Staphylococcus aureus USA300 LAC in response to vehicle and benzbromarone.

Project description:Compilation fo whole genome gene expression changes in Staphylococcus aureus USA300 LAC cultures grown in the presence of vehicle or the anti-gout drug benzbromarone. The drug was intially screened as effective against the agr quorum sensing system in Staphylococcus aureus AH1677. A microarray study using total RNA harvested from three cultures of Staphylococcus aureus USA300 LAC plus vehicle control and three cultures of Staphylococcus aureus USA300 LAC plus 12 uM benzbromarone.

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Changes in relative transcript amounts caused by ∆ftsH in Staphylococcus aureus USA300

Project description:Staphylococcus aureus is an important human pathogen causing skin infection and many serious diseases such as pneumonia, sepsis, and toxic shock syndrome. In the bacterium, the membrane-bound protease FtsH plays important roles in the bacterial resistance to various stresses. This study was initiated to explain the strain-specific aggregation of the ftsH-deletion mutant of the Newman strain. To understand the molecular basis of the phenotype, we identified FtsH substrate proteins by comparing the protein contents of two different strains, Newman and USA300, and found that, in the strain Newman, a single nucleotide change in the sensor histidine kinase saeS gene placed the SaeRS two-component system under the control of FtsH, leading to the strain-specific cell-aggregation phenotype. Not only does our study provide a new methodology for protease-substrate determination but it also demonstrates that even a single nucleotide polymorphism can rewire bacterial regulatory network, resulting in a strain-specific phenotype. Our study shows the pitfall of making sweeping conclusion based on experimental results from a single bacterial strain.

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RNA-seq of Wildtype Staphylococcus aureus USA300 NRS384

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Expression analysis of Staphylococcus aureus USA300 LAC in response to vehicle and benzbromarone.

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Regulation of gene expression by ArlRS in Staphylococcus aureus USA300 strain LAC

Project description:ArlRS is a two-component regulatory system in Staphylococcus aureus. Here we use RNA-sequencing to compare gene expression in a wild-type USA300 strain and an isogenic arlRS mutant.

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Gene expression analysis of Staphyloccoccus aureus USA300 vs USA400.

Project description:In the community and clinical settings MRSA infections are more commonly caused by a USA300 strain vs a USA400 strain. The study aims to compare gene expression patterns of Staphyloccoccus aureus USA300(reference) vs USA400(query) and to determine why USA400 is being replaced by a USA300 strain.

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Regulation of gene expression by MgrA in Staphylococcus aureus USA300 strain LAC

Project description:MgrA is a global regulator of gene expression in Staphylococcus aureus. Here we use RNA-sequencing to compare gene expression in a wild-type USA300 strain and an isogenic mgrA mutant.

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The secreted proteases Aur, ScpA, SspA and SspB suppress the virulence of Staphylococcus aureus USA300 by shaping the extracellular proteome

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Project description:The study aims to compare gene expression patterns of Staphyloccoccus aureus USA300 vs USA300 sae knockout. Samples were hybridized on aminosilane coated slides with 70-mer oligos.

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