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Wolbachia endosymbiont of Onchocerca volvulus

ABSTRACT: Nematode endosymbiont

PROVIDER: PRJNA35365 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	ADHE01.dat.gz	Other
	ADHE01.fasta.gz	Fasta.gz
	ADHE01.master.dat	Other

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Wolbachia endosymbiont of Onchocerca volvulus

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Wolbachia endosymbiont of Onchocerca volvulus

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Genomic diversity in Onchocerca volvulus and its Wolbachia endosymbiont.

Project description:Ongoing elimination efforts have altered the global distribution of Onchocerca volvulus, the agent of river blindness, and further population restructuring is expected as efforts continue. Therefore, a better understanding of population genetic processes and their effect on biogeography is needed to support elimination goals. We describe O. volvulus genome variation in 27 isolates from the early 1990s (before widespread mass treatment) from four distinct locales: Ecuador, Uganda, the West African forest and the West African savanna. We observed genetic substructuring between Ecuador and West Africa and between the West African forest and savanna bioclimes, with evidence of unidirectional gene flow from savanna to forest strains. We identified forest:savanna-discriminatory genomic regions and report a set of ancestry informative loci that can be used to differentiate between forest, savanna and admixed isolates, which has not previously been possible. We observed mito-nuclear discordance possibly stemming from incomplete lineage sorting. The catalogue of the nuclear, mitochondrial and endosymbiont DNA variants generated in this study will support future basic and translational onchocerciasis research, with particular relevance for ongoing control programmes, and boost efforts to characterize drug, vaccine and diagnostic targets.

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Project description:We sequenced total RNA from Dirofilaria immitis in order to generate the first tissue-specific gene expression profile of a filarial nematode and its Wolbachia endosymbiont. Examination of transcript levels in 7 different Dirofilaria immitis tissues, in duplicate, using Illumina GAIIx.

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Wolbachia endosymbiont of Onchocerca volvulus Genome sequencing

Project description:Genomic assembly of Wolbachia endosymbiont of nematode Onchocerca volvulus, as part of the 50 Helminth Genomes Initiative sequencing of the parasitic worms that have the greatest impact on human, agricultural and veterinary disease and cause significant global health issues particularly in the developing world, or those used as model organisms.

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