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Bos taurus

ABSTRACT: RNA-Seq transcriptomics and pathway analyses reveal potential regulatory genes and molecular mechanisms in high- and low-feed efficient Nordic dairy cattle

PROVIDER: PRJNA357463 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5110610_1.fastq.gz	Fastqsanger.gz
	SRR5110610_2.fastq.gz	Fastqsanger.gz
	SRR5110620_1.fastq.gz	Fastqsanger.gz
	SRR5110620_2.fastq.gz	Fastqsanger.gz
	SRR5110630_1.fastq.gz	Fastqsanger.gz

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RNA-Seq transcriptomics and pathway analyses reveal potential regulatory genes and molecular mechanisms in high- and low-feed efficient Nordic dairy cattle

Project description:The study investigated gene expression patterns in liver tissue to understand the biological functions of genes that are potentially involved in controlling / regulating feed efficiency in Nordic dairy cattle.

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Project description:Wandong cattle are an autochthonous Chinese breed used extensively for beef production. The breed tolerates extreme weather conditions and raw feed and are resistant to tick-borne diseases. However, the genetic basis of testis development and sperm production as well as breeding management is not well established in local cattle. In this study, we performed total RNA-Seq and comprehensively analyzed the circ-RNA expression profiling of the testes samples of six bulls at 3 years and 3 months of developmental age. In total, 17 013 circ-RNAs were identified, of which 681 circRNAs (P-adjust < 0.05) were differentially expressed (DE). Among these DE circ-RNAs, 579 were upregulated and 103 were downregulated in calf and bull testes. The Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses revealed that the identified target genes were classified into three broad functional categories, including biological process, cellular component, and molecular function, and were enriched in the lysine degradation, cell cycle, and cell adhesion molecule pathways.

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