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Mus musculus

ABSTRACT: Nuclear receptor corepressor (NCOR) and HDAC3 in hypothalamus [ChIP-Seq]

PROVIDER: PRJNA357599 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5114010.fastq.gz	Fastqsanger.gz
	SRR5114011.fastq.gz	Fastqsanger.gz
	SRR5114012.fastq.gz	Fastqsanger.gz
	SRR5114013.fastq.gz	Fastqsanger.gz
	SRR5114014.fastq.gz	Fastqsanger.gz

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Mus musculus

Project description:Nuclear receptor corepressor (NCOR) and HDAC3 in hypothalamus [RNA-Seq]

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Nuclear receptor corepressor (NCOR) and HDAC3 in hypothalamus

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Nuclear receptor corepressor (NCOR) and HDAC3 in hypothalamus [ChIP-Seq]

Project description:We determined genomic binding of HDAC3 in mouse hypothalamus by ChIP-seq, and identified target genes of the NCOR/HDAC3 complex in hypothalamus of NS-DADm (mutated deacetylase activation domain in NCORs) mice by RNA-seq.

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Nuclear receptor corepressor (NCOR) and HDAC3 in hypothalamus [RNA-Seq]

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Balanced Control of Thermogenesis by Nuclear Receptor Corepressors in Brown Adipose Tissue

Project description:Brown adipose tissue (BAT) is a key thermogenic organ, whose expression of Uncoupling Protein 1 (UCP1) and ability to maintain body temperature in response to acute cold exposure requires histone deacetylase 3 (HDAC3). HDAC3 exists in tight association with nuclear receptor corepressors NCoR1 and NCoR2(also known as Silencing Mediator of Retinoid and Thyroid Receptors, or SMRT), butthe functions of NCoR1/2 in BAT have not been established.Here we report that, as expected, genetic loss of NCoR1/2 in BAT (NCoR1/2 BAT-dKO) leads to loss of HDAC3 activity. In addition, HDAC3 is no longer bound at its physiological genomic sites in the absence of NCoR1/2, leading to a shared deregulation of BAT lipid metabolism between the NCoR1/2 BAT-dKO and HDAC3 BAT KO mice. Despite these commonalities, however, loss of NCoR1/2 in BAT does not phenocopy the cold sensitivity observed in the HDAC3 BAT-KO, nor does loss of either corepressor alone. Instead, BAT lacking NCoR1/2 is inflamed, particularly with respect to the IL-17 axis that increases thermogenic capacity by enhancing innervation. Integration of BAT RNA-seq and ChIP-seq data revealed that NCoR1/2 directly regulate Mmp9, which integrates extracellular matrix remodeling and inflammation. These findings reveal pleiotropic functions of the NCoR/HDAC3 corepressor complex in BAT, such that HDAC3-independent suppression of BAT inflammation counterbalances their stimulation of HDAC3 activity in the control of thermogenesis.

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Project description:We profiled gene expression in livers depleted of NCOR (nuclear receptor corepressor) along with wild-type livers as control.

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Gene expression profiling of liver-specific NCOR knockout mice

Project description:We profiled gene expression in livers depleted of NCOR (nuclear receptor corepressor) along with wild-type livers as control. NCOR floxed mice were intravenously injected with adeno-associated virus (AAV) expressing Cre or GFP. Livers were harvested at 2-weeks post-injection at 5pm (ZT10). Total RNA was extracted and hybridized to Affymetrx Mouse Gene 2.0 array.

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Project description:Nuclear Receptor Corepressors are Required for the Histone Deacetylase Activity of HDAC3 In Vivo (ChIP-Seq)

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