Amphibian
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA357939 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Dietary tannins alter growth, development, behavior, and the gut microbiome of larval amphibians
| PRJNA926636 | ENA
Project description:Fungal extracts from amphibians fungus Batrachochytrium dendrobatidis (NCBI taxon ID: 403673) and Batrachochytrium salamandrivorans (NCBI taxon ID: 1357716) from three life stages. Untargeted LC-MS/MS data acquired in positive mode.
2022-10-05 | MSV000090464 | GNPS
Project description:Lead (Pb) is a widespread environmental toxicant that can elicit a wide variety of adverse effects in aquatic species. In fish, exposure to Pb can induce oxidative stress and reduce antioxidant capacity and there is evidence that Pb-induced developmental abnormalities are the result of dysregulated metabolism pathways but to date, no studies have characterised the molecular mechanisms of lead toxicity in amphibians. To investigate this, we coupled transcriptomic responses and early-life stage toxicity testing to identify specific molecular mechanisms that drive the adverse effects of lead, in Xenopus laevis. Embryos were exposed to one of the concentrations (0, 70, 210 and 630 ng/L) of lead (II) nitrate starting from 2 days post fertilization (dpf) until 6 dpf and 21 dpf to examine the transcriptomic and apical responses, respectively. We observed common dysregulated pathways and with similar magnitude at medium and high lead concentrations, but a phenotypic response only with the highest lead level. RNA Seq analysis showed about ~250 differentially expressed genes that could be further categorized into KEGG pathways based on their involvement in key biological processes. The most dysregulated pathways were Glutathione metabolism, Cytochrome P450 (drug/ xenobiotic metabolism) and Steroid hormone biosynthesis. Developmental studies showed that tadpoles exposed to the highest Pb concentration (630 ug/L) had significantly decreased total length and higher proportion of developmental abnormalities. Therefore, evaluating gene expression responses can provide early indication of toxicological mechanisms of lead effects in amphibians. As with fish, dysregulated metabolic pathways are most likely the molecular mechanisms underlying lead toxicity in ELS amphibians and contribute to the altered growth and developmental abnormalities observed in this study.
2024-08-31 | GSE190080 | GEO
Project description:Chinese giant salamander (Andrias davidianus), Asiatic toad (Bufo gargarizans), and Heiban frog (Rana nigromaculata Hallowell) Raw sequence reads
| PRJNA378718 | ENA
Project description:Metagenome amplicon sequencing of amphibian skin bacteria
| PRJNA940133 | ENA