Project description:Dataset for a comparative analysis of protein profiles of three series of mouse macrophage cell line PMJ2R samples including infected with Tick-borne encephalitis virus, strain Hypr original isolate on the second (H2) and sixth day (H6) after infection was carried out using shotgun ultra-high resolution mass spectrometry.
Project description:Dataset for a comparative analysis of protein profiles of three series of mouse macrophage cell line PMJ2R samples including the control uninfected series (sample M) and infected with Tick-borne encephalitis virus, strain Hypr original isolate on the second (H2) and sixth day (H6) after infection was carried out using panoramic ultra-high resolution mass spectrometry. The analysis of measurements was performed using the proteomics search engine. The findings of the panoramic mass spectrometric analysis indicated that the protein composition of the cell samples is quite similar with respect to the number of identified proteins, protein composition and relative abundance. We identified a group of proteins specific for cell series H2 and H6.
Project description:Upon tick borne encephalitis virus exposure of brain-resident cells, astrocytes are important IFN-β producers that followed a biphasic response, which initially depends on MAVS- and later on MyD88/TRIF-signaling