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Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

ABSTRACT: Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

PROVIDER: PRJNA360106 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5144100.fastq.gz	Fastqsanger.gz
	SRR5144110.fastq.gz	Fastqsanger.gz
	SRR5144120.fastq.gz	Fastqsanger.gz
	SRR5144160.fastq.gz	Fastqsanger.gz
	SRR5144170.fastq.gz	Fastqsanger.gz

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Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function [miRNA-seq]

Project description:Hundreds of circular RNAs (circRNAs) are highly abundant in the mammalian brain, often with conserved expression. Here we show that the circRNA Cdr1as is massively bound by the microRNAs (miRNAs) miR-7 and miR-671 in human and mouse brains. When the Cdr1as locus was removed from the mouse genome, knockout animals displayed impaired sensorimotor gating-a deficit in the ability to filter out unnecessary information-which is associated with neuropsychiatric disorders. Electrophysiological recordings revealed dysfunctional synaptic transmission. Expression of miR-7 and miR-671 was specifically and posttranscriptionally misregulated in all brain regions analyzed. Expression of immediate early genes such as Fos, a direct miR-7 target, was enhanced in Cdr1as-deficient brains, providing a possible molecular link to the behavioral phenotype. Our data indicate an in vivo loss-of-function circRNA phenotype and suggest that interactions between Cdr1as and miRNAs are important for normal brain function.

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Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:To test the hypothesis that circRNAs might encode functional peptides in mammalian cells, we studied the long intergenic non-protein coding RNA, p53 induced transcript (LINC-PINT), which was previously reported as a tumor suppressor and connected p53 activation with polycomb repressive complex 2 (PRC2). We selected this long noncoding RNA (lncRNA) for further analysis because LINC-PINT has a long exon 2 which in accordance with the bioinformatical analyzed circular RNA standard.The following immunoblotting showed 87aa peptide level also decreased, indicating that this peptide is encoded by circPINTexon2. We name this circRNA encoded peptide PINT87aa. To investigate the possible regulatory role of PINT87aa, we did the expression micro array in PINT87aa stably transfect U251 or U87 glioblastoma cells and their control cells. The array analysis reveals that PINT87aa may involve in the cell cycle regulation, anti-apoptosis effects and multiple oncogenic signaling pathway activation.

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Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed

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