Project description:Colorectal cancer (CRC) is the third most common cancer worldwide and liver metastasis remains the major cause of death in CRC. Extensive genomic analysis provided valuable insight into the pathogenesis and progression of CRC. However, the major proteogenomic characterization of CRC liver metastasis is still unknown. We investigated proteogenomic characterization and performed comprehensive integrative genomic analysis of human colorectal cancer liver metastasis.
Project description:Current clinical therapy of non-small cell lung cancer depends on histo-pathological classification. This approach poorly predicts clinical outcome for individual patients. Proteogenomic characterization analysis holds promise to improve clinical stratification, thus paving the way for individualized therapy. We investigated proteogenomic characterization and performed comprehensive integrative genomic analysis of human large cell lung cancer. Here we analyzed proteomes of 29 paired normal lung tissues and large cell lung cancer, identified significantly deregulated proteins associated with large cell lung cancer.
Project description:Homo sapiens UICLM, up-regulated in colorectal cancer liver metastasis [Source:HGNC Symbol;Acc:HGNC:54869], is differentially expressed in 37 experiment(s);
Project description:Homo sapiens UICLM, up-regulated in colorectal cancer liver metastasis [Source:HGNC Symbol;Acc:HGNC:54869], is expressed in 19 baseline experiment(s);
Project description:Integrative analysis of colorectal cancer (CRC) ATAC-seq and RNA-seq revealed an epigenomic and transcriptomic remodeling during liver metastasis.
