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Schizosaccharomyces pombe

ABSTRACT: The histone acetyltransferase Mst2 prevents epigenetic silencing via specific acetylation of the ubiquitin ligase Brl1 [NGS data]

OTHER RELATED OMICS DATASETS IN: PXD005714GSE93434

PROVIDER: PRJNA361034 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5168060.fastq.gz	Fastqsanger.gz
	SRR5168061.fastq.gz	Fastqsanger.gz
	SRR5168062.fastq.gz	Fastqsanger.gz
	SRR5168055.fastq.gz	Fastqsanger.gz
	SRR5168056.fastq.gz	Fastqsanger.gz

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Schizosaccharomyces pombe

Project description:The histone acetyltransferase Mst2 prevents epigenetic silencing via specific acetylation of the ubiquitin ligase Brl1 [microarray data]

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The histone acetyltransferase Mst2 prevents epigenetic silencing via specific acetylation of the ubiquitin ligase Brl1

Project description:The histone acetyltransferase Mst2 prevents epigenetic silencing via specific acetylation of the ubiquitin ligase Brl1

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The histone acetyltransferase Mst2 prevents epigenetic silencing via specific acetylation of the ubiquitin ligase Brl1 [NGS data]

Project description:Faithful propagation of distinct chromatin states is crucial to maintain cellular identity. Whereas mechanisms that sustain repressed states have been intensely studied, regulatory circuits that protect active chromatin from inactivating signals are not well understood. Here we report the discovery of a self-reinforcing feedback loop that preserves the transcription-competent state of RNA polymerase II transcribed genes. We found that the chromatin reader Pdp3 recruits the histone acetyltransferase Mst2 to H3K36me3 marked chromatin. Thereby, Mst2 binds to all transcriptionally active regions genome-wide. Besides histone H3K14, Mst2 specifically acetylates Brl1, a component of the histone H2B ubiquitin ligase complex (HULC). Brl1 acetylation results in increased histone H2B ubiquitination, which together with H3K14ac positively feeds back on transcription and prevents assembly of ectopic heterochromatin. Our work uncovers a molecular pathway that secures epigenome integrity and highlights the importance of opposing feedback loops for the partitioning of chromatin into transcriptionally active and inactive states.

2017-06-22 | GSE93432 | GEO

The histone acetyltransferase Mst2 prevents epigenetic silencing via specific acetylation of the ubiquitin ligase Brl1 [microarray data]

2017-06-22 | GSE93433 | GEO

The histone acetyltransferase Mst2 protects active chromatin from epigenetic silencing by acetylating the ubiquitin ligase Brl1

Project description:Faithful propagation of functionally distinct chromatin states is crucial for maintaining cellular identity, and its breakdown can lead to diseases such as cancer. Whereas mechanisms that sustain repressed states have been intensely studied, regulatory circuits that protect active chromatin from inactivating signals are not well understood. Here we discover a self-reinforcing feedback loop that preserves the transcription-competent state of RNA polymerase II transcribed genes. We found that the chromatin reader Pdp3 recruits the histone acetyltransferase Mst2 to H3K36me3 marked chromatin. Thereby, Mst2 binds to all transcriptionally active regions genome-wide. Besides acetylating histone H3K14, Mst2 also acetylates Brl1, a component of the histone H2B ubiquitin ligase complex. Brl1 acetylation results in increased histone H2B ubiquitination, which together with H3K14ac positively feeds back on transcription and prevents assembly of ectopic heterochromatin. Our work uncovers a molecular pathway that secures epigenome integrity and highlights the importance of opposing feedback loops for the partitioning of chromatin into transcriptionally active and inactive states.

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Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation

Project description:Analysis of histone acetyl transferases (HATs) from the MYST and GNAT families in S. pombe to identify functional differences or overlap with regard to gene expression. Mutations were made to Elp3 and Gcn5 (GNAT family), and to Mst2 (MYST family). Mutants showed distinct phenotypes which were repressed or enhanced by mutant combinations. This SuperSeries is composed of the following subset Series: GSE17259: S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation, dual-channel dataset GSE17262: S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation, Affymetrix dataset Refer to individual Series

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Schizosaccharomyces pombe

Project description:S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation, Affymetrix dataset

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Schizosaccharomyces pombe

Project description:S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation, dual-channel dataset

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Schizosaccharomyces pombe

Project description:Swi1/Timeless prevents repeat instability at fission yeast telomeres

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Schizosaccharomyces pombe

Project description:H3K14 and H4 acetylation in wild-type cells of S. pombe