Chlorocebus aethiops
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA362785 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:MDFIC alteration of the GR transcriptome in COS-1 cells depends on S211 phosphorylation of GR
| PRJNA362784 | ENA
Project description:Gene expressions regulated by N/C interacting and non-interactiong GR
| PRJNA311349 | ENA
Project description:Genome-wide analysis of simian virus 40 infected cells
| PRJNA361108 | ENA
Project description:Chlorocebus aethiops Transcriptome or Gene expression
| PRJNA937401 | ENA
Project description:Chlorocebus aethiops Transcriptome or Gene expression
| PRJNA182762 | ENA
Project description:Chlorocebus aethiops Transcriptome or Gene expression
| PRJNA937394 | ENA
Project description:We describe a genome reference of the African green monkey or vervet (Chlorocebus aethiops). This member of the Old World monkey (OWM) superfamily is uniquely valuable for genetic investigations of simian immunodeficiency virus (SIV), for which it is the most abundant natural host species, and of a wide range of health-related phenotypes assessed in Caribbean vervets (C. a. sabaeus), whose numbers have expanded dramatically since Europeans introduced small numbers of their ancestors from West Africa during the colonial era. We use the reference to characterize the genomic relationship between vervets and other primates, the intra-generic phylogeny of vervet subspecies, and genome-wide structural variations of a pedigreed C. a. sabaeus population. Through comparative analyses with human and rhesus macaque, we characterize at high resolution the unique chromosomal fission events that differentiate the vervets and their close relatives from most other catarrhine primates, in whom karyotype is highly conserved. We also provide a summary of transposable elements and contrast these with the rhesus macaque and human. Analysis of sequenced genomes representing each of the main vervet subspecies supports previously hypothesized relationships between these populations, which range across most of sub-Saharan Africa, while uncovering high levels of genetic diversity within each. Sequence-based analyses of major histocompatibility complex (MHC) polymorphisms reveal extremely low diversity in Caribbean C. a. sabaeus vervets, compared to vervets from putatively ancestral West African regions. In the C. a. sabaeus research population, we discover the first structural variations that are, in some cases, predicted to have a deleterious effect; future studies will determine the phenotypic impact of these variations.
| S-EPMC4665013 | biostudies-literature
Project description:Differential gene expression between WT MARC-145 cells and MARC-145 cells stably expressing Non-Structural Protein 11 of Porcine Respiratory and Reproductive Syndrome Virus
| PRJNA227443 | ENA
Project description:Genome-wide small RNAs analysis of simian virus 40 infected cells
| PRJNA360673 | ENA