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Pseudomonas panipatensis strain:Esp-1 | isolate:CCM 7469

ABSTRACT: Pseudomonas panipatensis Esp-1 genome sequencing

PROVIDER: PRJNA369935 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5831897_1.fastq.gz	Fastqsanger.gz
	SRR5831897_2.fastq.gz	Fastqsanger.gz

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DNA Methyltransferase M.PaeTBCFI in a chronically adapted Pseudomonas aeruginosa strain

Project description:Pseudomonas aeruginosa is an opportunistic pathogen which causes acute and chronic infections that are difficult to treat. Comparative genomic analysis has showed a great genome diversity among P. aeruginosa clinical strains and revealed important regulatory traits during chronic adaptation. While current investigation of epigenetics of P. aeruginosa is still lacking, understanding the epigenetic regulation may provide biomarkers for diagnosis and reveal important regulatory mechanisms. The present study focused on characterization of DNA methyltransferases (MTases) in a chronically adapted P. aeruginosa clinical strain TBCF10839. Single-molecule real-time sequencing (SMRT-seq) was used to characterize the methylome of TBCF. RCCANNNNNNNTGAR and TRGANNNNNNTGC were identified as target motifs of DNA MTases, M.PaeTBCFI and M.PaeTBCFII, respectively.

2023-07-22 | GSE209530 | GEO

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