Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Phaffia australis strain:CBS 14095

ABSTRACT: Phaffia australis strain:CBS 14095 Genome sequencing and assembly

PROVIDER: PRJNA371751 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR12203029_1.fastq.gz	Fastqsanger.gz
	SRR12203029_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 3 of 3

Similar Datasets

Phaffia tasmanica strain:CBS 14096

Project description:Phaffia tasmanica strain:CBS 14096 Genome sequencing and assembly

| PRJNA371754 | ENA

Phaffia rhodozyma strain:CBS 6938

Project description:Phaffia rhodozyma strain:CBS 6938 Genome sequencing and assembly

| PRJNA1053634 | ENA

Phaffia rhodozyma strain:CBS 7918

Project description:Phaffia rhodozyma CBS 7918 genome sequencing and assembly

| PRJNA306035 | ENA

Subversion of host innate immunity by Rickettsia australis via a modified autophagic response in macrophages

Project description:We recently reported that the in vitro and in vivo survival of Rickettsia australis are Atg5-dependent, in association with an inhibited level of anti-rickettsial cytokine, IL-1β. In the present study, we sought to investigate how R. australis interacts with host innate immunity via an Atg5-dependent autophagic response. We found that the serum levels of IFN-γ and G-CSF in R. australis-infected Atg5flox/floxLyz-Cre mice were significantly less compared to Atg5flox/flox mice, accompanied by significantly lower rickettsial loads in tissues with inflammatory cellular infiltrations including neutrophils. R. australis infection differentially regulated a significant number of genes in bone marrow-derived macrophages (BMMs) in an Atg5-depdent fashion as determined by RNA sequencing and Ingenuity Pathway Analysis, including genes in the molecular networks of IL-1 family cytokines and PI3K-Akt-mTOR. The secretion levels of inflammatory cytokines, such as IL-1α, IL-18, TNF-α, and IL-6, by R. australis-infected Atg5flox/floxLyz-Cre BMMs were significantly greater compared to infected Atg5flox/flox BMMs. Interestingly, R. australis significantly increased the levels of phosphorylated mTOR and P70S6K at a time when the autophagic response is induced. Rapamycin treatment nearly abolished the phosphorylated mTOR and P70S6K but did not promote significant autophagic flux during R. australis infection. These results highlight that R. australis modulates an Atg5-dependent autophagic response, which is not sensitive to regulation by mTORC1 signaling in macrophages. Overall, we demonstrate that R. australis counteracts host innate immunity including IL-1β-dependent inflammatory response to support the bacterial survival via an mTORC1-resistant autophagic response in macrophages.

2021-04-06 | GSE171160 | GEO

Phaffia rhodozyma strain:DW6

Project description:Phaffia rhodozyma strain:DW6 Genome sequencing and assembly

| PRJNA823810 | ENA

Phaffia rhodozyma strain:PR106

Project description:Phaffia rhodozyma strain:PR106 Genome sequencing and assembly

| PRJNA690662 | ENA

Expression analysis of Pichia stipitis CBS 6054 grown in glucose or xylose

Project description:Investigation of whole genome gene expression level changes in Pichia stipitis CBS 6054 grown aerobically in xylose, compared to the same strain grown aerobically in glucose.

2011-10-20 | GSE24854 | GEO

Phaffia rhodozyma

Project description:Phaffia rhodozyma Genome sequencing and assembly

| PRJNA704195 | ENA

Transcriptome data on gene expression in Drosophila strains with deletions of sulfur metabolism genes: CBS and CSE

Project description:To reveal the role of sulfur metabolism genes in memory formation processes, transcriptome libraries were obtained from the heads of 5-day-old naive males. The libraries were generated from Drosophila strains created in our laboratory with deleted cbs genes ( CBS-/-(5) and CBS-/-(8), cse (CSE-/-) and strains with double deletion of cbs and cse genes (CBS-/-,CSE-/-(1) and (CBS-/-,CSE-/-(2). Strain 58492, in which deletions were introduced by the CRISP/CAS9 method, was used as a control strain.

2022-04-14 | GSE200397 | GEO

Phaffia

Project description:Phaffia sp. overview

| PRJNA436611 | ENA