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Mus musculus

ABSTRACT: Innate versus adaptive lymphoid cell fate choice is controlled by the E-Id protein axis [RNA-Seq]

PROVIDER: PRJNA376693 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5282920_1.fastq.gz	Fastqsanger.gz
	SRR5282920_2.fastq.gz	Fastqsanger.gz
	SRR5282921_1.fastq.gz	Fastqsanger.gz
	SRR5282921_2.fastq.gz	Fastqsanger.gz
	SRR5282922_1.fastq.gz	Fastqsanger.gz

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Innate versus adaptive lymphoid cell fate choice is controlled by the E-Id protein axis

Project description:Innate versus adaptive lymphoid cell fate choice is controlled by the E-Id protein axis

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Project description:Innate versus adaptive lymphoid cell fate choice is controlled by the E-Id protein axis [ATAC-Seq]

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Innate versus adaptive lymphoid cell fate choice is controlled by the E-Id protein axis [ATAC-Seq]

Project description:The lymphoid branch of the immune defense is composed of innate and adaptive immune cells. Using multiple genetic strategies we demonstrate that in the thymus E2A and HEB act in synergy to establish T cell identity and to suppress the aberrant development of innate lymphoid cells that include ILC2 and LTi-like cells. We found that E2A and HEB induce T cell fate by activating the expression of an ensemble of genes encoding for proteins associated with Notch- and pre-TCR signaling and to promote TCRβ antigen receptor assembly. We show that E2A and HEB act in early T progenitors (ETPs) to establish and maintain a T-lineage specific enhancer repertoire, including regulatory elements associated with the Notch1/3 and Rag1/2 gene loci. Based on these and previous observations we propose that the E-Id protein axis specifies innate versus adaptive lymphoid cell fate.

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Innate versus adaptive lymphoid cell fate choice is controlled by the E-Id protein axis [RNA-Seq]

2017-06-01 | GSE95337 | GEO

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Project description:Regulation of lymphoid versus myeloid fate choice by Mef2c

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Distinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lymphoid Cells

Project description:Distinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lymphoid Cells

| PRJNA314321 | ENA

A genetic circuitry linking Id-proteins (Id2 and Id3) and the AKT-FOXO-mTORC1 axis to suppress innate-variant TFH cell development, maintain T cell quiescence and prevent lymphomagenesis.

Project description:It is now well established that the E- and Id-protein axis regulates multiple steps in lymphocyte development. However, it remains unknown as to how E- and Id-proteins mechanistically enforce and maintain the naïve T cell fate. Here we show that Id2 and Id3 suppressed the development and expansion of innate-variant TFH cells. Innate-variant TFH cells required MHC Class I-like signalling and were associated with germinal center B cell development. We found that Id2 and Id3 induced Foxo1 and Foxp1 expression to antagonize the activation of TFH transcription signature. We show that Id2 and Id3 acted upstream of the Hif1a/Foxo/AKT/mTORC1 pathway as well as the c-myc/p19Arf module to control cellular expansion and activation. We found that mice depleted for Id2 and Id3 expression developed colitis and αβ T cell lymphomas. Lymphomas depleted for Id2 and Id3 expression displayed elevated levels of c-myc whereas p19Arf abundance declined. Transcription signatures of Id2- and Id3-depleted lymphomas revealed similarities with genetic deficiencies associated with Burkitt lymphoma. We propose that in response to antigen receptor and/or cytokine signaling the E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hifa and c-myc/p19Arf pathways to control cellular expansion and homeostatic proliferation. RNA-seq data of 5 of wild type CD4SP cells, 3 of wild type Tfh cells, 3 of Id3-/- CD4SP cells, 3 of Id2-/-Id3-/-(dKO) CD4SP cells, and 6 of Id2-/-Id3-/- lymphoma cells.

2015-03-04 | E-GEOD-64779 | biostudies-arrayexpress

Homo sapiens

Project description:Distinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lymphoid Cells [gene expression]

| PRJNA314326 | ENA

A genetic circuitry linking Id-proteins (Id2 and Id3) and the AKT-FOXO-mTORC1 axis to suppress innate-variant TFH cell development, maintain T cell quiescence and prevent lymphomagenesis.

2015-03-04 | GSE64779 | GEO

Homo sapiens

Project description:Distinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lymphoid Cells [ChIP-seq & ATAC-seq]

| PRJNA309990 | ENA