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Possible molecular mechanisms by which an essential oil blend from star anise, rosemary, thyme, and oregano and saponins increase the performance and ileal protein digestibility of growing broilers

ABSTRACT: Possible molecular mechanisms by which an essential oil blend from star anise, rosemary, thyme, and oregano and saponins increase the performance and ileal protein digestibility of growing broilers

PROVIDER: PRJNA377537 | ENA |

REPOSITORIES: ENA

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Possible molecular mechanisms by which an essential oil blend from star anise, rosemary, thyme, and oregano and saponins increase the performance and ileal protein digestibility of growing broilers [Liver]

Project description:Individual male broilers (Cobb500; n=16) were allotted to 4 experimental diets containing either no phytogenic feed additives, an essential oil blend, saponin extract or a combination of both phytogenic preparations. Liver samples were used for transcriptome profiling.

2017-12-31 | GSE95566 | GEO

Project description:Individual male broilers (Cobb500; n=16) were allotted to 4 experimental diets containing either no phytogenic feed additives, an essential oil blend, saponin extract or a combination of both phytogenic preparations. Jejunum samples were used for transcriptome profiling.

2017-12-31 | GSE95559 | GEO

Gallus gallus

Project description:Possible molecular mechanisms by which an essential oil blend from star anise, rosemary, thyme, and oregano and saponins increase the performance and ileal protein digestibility of growing broilers [Liver]

| PRJNA377541 | ENA

Gallus gallus

| PRJNA377542 | ENA

Possible molecular mechanisms by which an essential oil blend from star anise, rosemary, thyme, and oregano and saponins increase the performance and ileal protein digestibility of growing broilers

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-12-31 | GSE95568 | GEO

Tilapia Oil-Blend Microbiome

Project description:Tilapia Oil-Blend Microbiome raw sequence reads

| PRJNA824458 | ENA

A novel micronutrient blend mimics calorie restriction transcriptomics in multiple tissues of mice and increases life and healthspan in C. Elegans

Project description:Calorie restriction is a major intervention consistently demonstrated to retard aging and delay age-associated diseases. A novel micronutrient blend, a putative calorie restriction mimetic, was developed based on a screening tool we previously described. Whole transcriptomic analysis was examined in brain cortex, skeletal muscle and heart in three groups of mice: old controls (30 months), old + calorie restriction and old + novel micronutrient blend. The micronutrient blend elicited transcriptomic changes in a manner similar to those in the calorie-restricted group and unique from those in the control group. Subgroup analysis revealed that nuclear hormone receptor, proteasome complex and angiotensinogen genes, all of which are known to be directly related to the aging process, were the most affected by the micronutrient blend and by calorie restriction. Thus, these three genes may be considered master regulators of the favorable effects of calorie restriction and of the micronutrient blend. Based on the calorie restriction mimetic effects on transcriptomics, it was hypothesized that the micronutrient blend would promotes longevity and vitality. To test this hypothesis, a functional analysis in C. Elegans was used to examine the effects of the micronutrient blend on longevity and biomarkers of vitality. Results indicate that feeding C. Elegans the micronutrient blend increased longevity as well as vitality. Further studies are required to confirm that the calorie restriction mimicking benefits described here are elicited by the micronutrient blend in humans.

2020-11-05 | E-MTAB-8506 | biostudies-arrayexpress

Administration of Probiotic Blend in Pancreatic Cancer Xenografted mice

Project description:Gemcitabine treatment shifts the intestinal microbiota of PC mice towards an inflammatory profile which may worsen mucositis and side effects observed upon chemotherapy. We explored the effect of a specific probiotics blend administered, with or without gemcitabine treatment, to PC xenografted mice.

2023-06-28 | E-MTAB-10676 | biostudies-arrayexpress

Administration of Probiotic Blend in Pancreatic Cancer Xenografted mice

Project description:Administration of Probiotic Blend in Pancreatic Cancer Xenografted mice

| PRJEB46072 | ENA

Broilers divergently selected for digestibility differ for their digestive microbial ecosystems.

Project description:Improving the digestive efficiency of broiler chickens (Gallus gallus) could reduce organic waste, increase the use of alternative feed not used for human consumption and reduce the impact of feed in production costs. By selecting chicken lines divergently for their digestive efficiency, we showed previously that digestive efficiency is under genetic control and that the two resulting divergent lines, D+ (high digestive efficiency or "digestibility +") and D- (low digestive efficiency or "digestibility -"), also differ for the abundance of specific bacteria in their caeca. Here we perform a more extensive census of the bacteria present in the digestive microbiota of 60 chickens selected for their low apparent metabolizable energy corrected for nitrogen balance (AMEn-) or high (AMEn+) digestive efficiency in a [D+ x D-] F8 progeny of 200 individuals. We sequenced the 16S rRNA genes of the ileal, jejunal and caecal microbiotas, and compared the compositions and predicted functions of microbiotas from the different intestinal segments for 20 AMEn+ and 19 AMEn- birds. The intestinal segment of origin was the main factor structuring the samples. The caecal microbiota was the most impacted by the differences in digestive efficiency, with 41 bacterial species with abundances differing between highly and poorly efficient birds. Furthermore, we predicted that the caecal microbiota of efficient birds might be enriched in genes contributing to the degradation of short chain fatty acids (SCFA) from non-starch polysaccharides. These results confirm the impact of the genetic selection led on digestibility on the caecal microbiota taxonomic composition. They open the way toward the identification of specific, causal genes of the host controlling variations in the abundances of bacterial taxons.

| S-EPMC7233591 | biostudies-literature

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