Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Small RNA Sequencing of Papillary Thyroid Carcinoma with Lymph Node Metastasis

PROVIDER: PRJNA378313 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5317820.fastq.gz	Fastqsanger.gz
	SRR5317821.fastq.gz	Fastqsanger.gz
	SRR5317822.fastq.gz	Fastqsanger.gz
	SRR5317823.fastq.gz	Fastqsanger.gz
	SRR5317824.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 10

Similar Datasets

Homo sapiens

Project description:Small RNA Sequencing of Papillary Thyroid Carcinoma without Lymph Node Metastasis

| PRJNA389360 | ENA

miRNA expression profiles in non-aggressive, invasive and metastatic papillary thyroid cancer

Project description:Paillary thyroid cancer (PTC) is the most common type of thyroid malignancy. Extrathyroidal invasion (ETİ), lymph node metastasis, and distance organ metastasis is poor prognostic factor in PTC. The metastasis is still a leading cause of papillary thyroid cancer death. The early detection of metastatic signature is crucial for identification of thyroid cancer prognosis and personalized therapeutic strategies. In the present study, we present thyroid cancer metastasis and invasivenes related miRNAs identified by comprehensive miRNA expression profiling of formalin-fixed paraffin embedded (FFPE) thyroid tissues obtained from patients belonging to intrathyroidal, invasive and metastatic thyroid carcinoma groups

2020-03-23 | GSE129878 | GEO

Single cell profiling of primary and paired metastatic lymph node tumors and adjacent normal thyroid in a papillary thyroid carcinoma patient

Project description:In the present study, we measured gene expression levels of 3 tissue samples from a young female patient with papillary thyroid carcinoma (PTC) using scRNA-seq technology and tried to uncover the mechanisms of promoting lymph node metastasis of PTC.

2023-08-18 | GSE241184 | GEO

mRNA expression profiles in non-aggressive, invasive and metastatic papillary thyroid cancer

2020-03-23 | GSE129879 | GEO

Genetic expressions alteration affect on lateral neck node metastasis of thyroid papillary microcarcinoma

Project description:We performed oligonucleotide microarray analysis to assess the genetic expression alteration wich affected on lateral neck node metastasis of thyroid papillary microcarcinoma(PTMC). We performed microarray analysis in three PTMCs without cervical lymph-node metastases (N0), and five PTMCs with lateral neck-node metastasis (N1b) at initial diagnosis, using an Illumina HumanHT-12 v4.0 Expression BeadChip.

2019-11-12 | GSE129562 | GEO

Project description:Genomic characterization of papillary thyroid carcinoma with lymph node metastases

| PRJNA1111258 | ENA

Patients with metastatic urothelial carcinoma

Project description:Samples from three patients with urothelial carcinoma and paired lymph node metastases and distant metastases. Patient 1: Muscle invasive tumor and lymph node metastasis. Patient 2: Muscle invasive tumor, lymph node metastasis, and distant metastasis in the small intestine. Patient 3: T1b tumor, lymph node metastasis, and distant metastasis in the lung

| EGAS00001002114 | EGA

Sequencing of the whole transcriptome of papillary thyroid cancer and lymph node metastases

Project description:This data was gathered from three patients who had papillary thyroid carcinoma with paired lymph node metastases. The goal of this study was to determine critical genes and pathway that influence the occurrence of lymph node metastasis in PTC patients. A total of 6 samples were analyzed, resulting in an average of 10.16 GB of data per sample. 1,967 new genes were predicted; 19,430 genes were detected as expressed, of which 17,890 were known genes and 1,540 were predicted new genes; 27,495 new transcripts were found, of which 15,846 belonged to known genes. There were a total of 27,495 novel transcripts discovered, with 15,846 belonging to new variable splice isoforms of known protein-coding genes, 1,967 to transcripts of new protein-coding genes, and 9,682 to long-stranded non-coding RNAs.

2023-05-31 | GSE202413 | GEO

p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer.

Project description:Anaplastic thyroid carcinoma (ATC) has among the worst prognosis of any solid malignancy. The low incidence of the disease has in part precluded systematic clinical trials and tissue collection, and there has been little progress in developing effective therapies. BRAF and TP53 mutations co-occur in a high proportion of ATC, particularly those associated with a precursor papillary thyroid carcinoma (PTC). In order to develop an adult-onset model of BRAF-mutant anaplastic thyroid carcinoma, we generated a novel thyroid-specific CreER transgenic mouse. We utilize a Cre-regulated BrafV600E mouse and a conditional Trp53 allelic series to demonstrate that p53 constrains progression from papillary to anaplastic thyroid carcinoma. Gene expression and immunohistochemical analyses of murine tumors identified the cardinal features of human ATC including loss of differentiation, local invasion, distant metastasis and rapid lethality. We employed small animal ultrasound imaging to monitor autochthonous tumors, and show that treatment with the selective BRAF inhibitor PLX4720 improved survival, but did not lead to tumor regression or suppress signaling through the MAPK pathway. Combination of PLX4720 and the MEK inhibitor PD0325901 more completely suppressed MAPK pathway activation in mouse and human ATC cell lines, and improved the structural response and survival of ATC-bearing animals. This model expands the limited repertoire of autochthonous models of clinically aggressive thyroid cancer, and these data suggest that small molecule MAPK pathway inhibitors hold clinical promise in the treatment of advanced thyroid carcinoma. Total RNA from five murine papillary thyroid carcinoma (PTC) tumors and five murine anaplastic thyroid carcinoma (ATC) tumors was analyzed.

2014-04-02 | E-GEOD-55933 | biostudies-arrayexpress

Quantification of microRNA expression in early-stage oral squamous cell carcinoma

Project description:Microarray was used to find out the differentially expressed in tumor sites of early-stage oral squamous cell carcinoma compared with Normal parts. Furthermore, we compared cases of early-stage oral squamous cell carcinoma with lymph node metastasis with cases without lymph node metastasis. The miRNAs obtained may not only serve as predictive biomarkers for lymph node metastasis, but may also be used further to understand disease.

2023-08-22 | GSE241289 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data