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Danio rerio

ABSTRACT: A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development [ATAC-seq]

PROVIDER: PRJNA378506 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5320540_1.fastq.gz	Fastqsanger.gz
	SRR5320540_2.fastq.gz	Fastqsanger.gz
	SRR5320541_1.fastq.gz	Fastqsanger.gz
	SRR5320541_2.fastq.gz	Fastqsanger.gz
	SRR5320534_1.fastq.gz	Fastqsanger.gz

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Danio rerio

Project description:A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development [RNA-seq]

| PRJNA378505 | ENA

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development

Project description:A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development

| PRJNA378502 | ENA

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development [RNA-seq]

Project description:The neural crest is a dynamic progenitor cell population that arises at the border of neural and non-neural ectoderm. The inductive roles of FGF, Wnt, and BMP at the neural plate border are well established, but the signals required for subsequent neural crest development remain poorly characterized. Here, we conducted a screen in primary zebrafish embryo cultures for chemicals that decrease neural crest formation, as read out by crestin:EGFP expression. We found that the natural product caffeic acid phenethyl ester (CAPE) disrupts neural crest gene expression, migration, and melanocytic differentiation by reducing Sox10 activity. CAPE inhibits PI3K/Akt signaling specifically in FGF-stimulated cells, and neural crest defects in CAPE-treated embryos are suppressed by constitutively active Akt1. Inhibition of Akt activity by constitutively active PTEN similarly decreases crestin expression and Sox10 activity. Our study has identified Akt as a novel intracellular pathway required for neural crest development.

2017-08-17 | GSE95814 | GEO

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development [ATAC-seq]

2017-08-17 | GSE95813 | GEO

Danio rerio

Project description:Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis

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Project description:A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation [zebrafish ChIP-seq]

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Danio rerio

Project description:A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation [zebrafish RNA-Seq]

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Danio rerio

Project description:Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish

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Zebrafish (Danio rerio) neural crest cell RNA-sequencing

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