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Mus musculus

ABSTRACT: Direct conversion of mouse fibroblasts into cholangiocyte progenitor cells

PROVIDER: PRJNA382180 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5441553_1.fastq.gz	Fastqsanger.gz
	SRR5441553_2.fastq.gz	Fastqsanger.gz
	SRR5441554_1.fastq.gz	Fastqsanger.gz
	SRR5441554_2.fastq.gz	Fastqsanger.gz
	SRR5441555_1.fastq.gz	Fastqsanger.gz

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Direct conversion of mouse fibroblasts into cholangiocyte progenitor cells

Project description:We describe that Hnf1α and Foxa3 dramatically facilitate the robust generation of iHepSCs. Notably, the prolonged in vitro culture of Hnf1α and Foxa3 derived iHepSCs induce Notch signaling-mediated secondary conversion into cholangiocyte progenitor-like cells displaying the dramatically enhanced differentiation capacity into the mature cholangiocytes in vitro and in vivo. Our study provides the novel two-step approach for obtaining cholangiocyte progenitor-like cells using defined factors.

2018-03-06 | GSE97507 | GEO

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