Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rattus norvegicus

ABSTRACT: Hippocampal subfield transcriptomic profiles: Regional vulnerability to age and cognitive impairment

PROVIDER: PRJNA382422 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5442430.fastq.gz	Fastqsanger.gz
	SRR5442440.fastq.gz	Fastqsanger.gz
	SRR5442450.fastq.gz	Fastqsanger.gz
	SRR5442460.fastq.gz	Fastqsanger.gz
	SRR5442470.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 132

Similar Datasets

Rattus norvegicus

Project description:Hippocampal pathways in cognitive impairment

| PRJNA96943 | ENA

Rattus norvegicus

Project description:Regional commonalities and specificities of age-related changes in hippocampal transcriptome.

| PRJNA239377 | ENA

Rattus norvegicus

Project description:Transcriptional profiles of rodent hippocampal CA1 tissue during aging and cognitive decline

| PRJNA104011 | ENA

Rattus norvegicus

Project description:DNA Methylation of Synaptic Genes in the Prefrontal Cortex is Associated with Aging and Age-Related Cognitive Impairment

| PRJNA382428 | ENA

Rattus norvegicus

Project description:Changes in intestinal microflora and it's metabolites underlie the cognitive impairment in preterm rats

| PRJNA736839 | ENA

Next-Generation sequencing of the hippocampus transcriptome in aged and cognitive impaired rats

Project description:The current study employed next generation RNA sequencing using two different platforms (Illumina and Ion Proton) to examine gene expression differences related to brain aging, cognitive decline, and hippocampus subregions (CA1, CA3, DG). Young and aged rats were trained on a spatial episodic memory task. The results describe regional differences in gene expression and point to regional differences in vulnerability to aging. Aging was associated with increased expression of immune response related genes, particularly in the dentate gyrus. For the memory task, impaired performance of aged animals was linked to the regulation of Ca2+ and synaptic function in region CA1. Finally, we provided a transcriptomic characterization of the three subregions regardless of age or cognitive status, highlighting and confirming a correspondence between cytoarchitectural boundaries and molecular profiling.

2017-12-08 | GSE101798 | GEO

Transcription profile of aging and cognitive-related genes in the medial prefrontal cortex and hippocampal region CA1

Project description:This study focused on transcription in the medial PFC (mPFC) as a function of age and cognition. Young and aged F344 rats were characterized on tasks, attentional set shift and spatial memory, which depend on the mPFC and hippocampus, respectively. Differences in transcription associated with age and cognitive function were examined using RNA sequencing to construct transcriptomic profiles for the mPFC, white matter, and region CA1 of the hippocampus. The results indicate regional differences in vulnerability to aging associated with increased expression of immune and defense response genes and a decline in synaptic and neural activity genes. Importantly, we provide evidence for region specific transcription related to behavior. In particular, expression of transcriptional regulators and neural activity-related immediate-early genes (IEGs) are increased in the mPFC of aged animals that exhibit delayed set shift behavior; relative to age-matched animals that exhibit set shift behavior similar to younger animals. The study contains 11 young and 20 aged rats for the mPFC and CA1 samples, which were used to investigate expression patterns associated with aging and behavior. White matter samples were used to investigate an age-related effect with 8 young and 9 aged rats.

2016-05-17 | E-GEOD-75772 | biostudies-arrayexpress

Rattus norvegicus

Project description:Vitamin D Prevents Cognitive Decline and Enhances Hippocampal Synaptic Function in Aging Rats

| PRJNA260784 | ENA

Rattus norvegicus

Project description:RNA profiles of rat olfactory epithelia : individual and age related variations (age experiment)

| PRJNA123079 | ENA

Hippocampal single-cell atlas screening unveils disrupted neuroglial system in postoperative cognitive impairment

Project description:This study investigates the roles of neurons, microglia, astrocytes, and oligodendrocytes in the pathogenesis of postoperative cognitive impairment, focusing on a dysregulated glia-neuron cycle. We utilized 18-month male C57BL/6 mice to model this condition, conducting single-cell RNA sequencing in the hippocampus to explore the neuroglial interactions and their implications in neuroinflammation, synaptic dysfunction, and myelin loss. This dataset includes transcriptomic profiles aimed at decoding the cellular communication in aged hippocampal cells and assessing the impact of therapeutic interventions on postoperative cognitive decline.

2024-11-14 | GSE267933 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data