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Genome-wide analysis of the altered gene expression in the transgenic mice ectopically expressing the human SRY.

ABSTRACT: Genome-wide analysis of the altered gene expression in the transgenic mice ectopically expressing the human SRY.

PROVIDER: PRJNA383039 | ENA |

REPOSITORIES: ENA

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Genome-wide analysis of the altered gene expression in the transgenic mice ectopically expressing the human SRY. [lung]

Project description:Analysis of the effects of an ectopically expressed human SRY (hSRY) on gene expression in the mouse lung. We hypothesize that aberrant expression of the human SRY gene could affect the development and physiology of transgenic mice. To test this hypothesis we have established a Cre-LoxP transgene activation system, thereby activating and expressing the hSRY transgene at the single-cell embryonic stage. Such transgenic mice were born of similar sizes as non-transgenic littermates, but retard in postnatal growth and all die within two weeks of age. To determine the molecular changes associated with such phenotypes, we have analyzed the transcriptomes of lungs of pups expressing (hSRY-ON) and not-expressing (hSRY-OFF) the hSRY transgene. The results provide important information demonstrating that ectopic expression of hSRY resulted in altered expression patterns of numerous genes associating with the development of respiratory system and pathogenesis of respiratory diseases in the lung.

2017-04-16 | GSE97845 | GEO

Genome-wide analysis of the altered gene expression in the transgenic mice ectopically expressing the human SRY. [heart]

Project description:Analysis of the effects of an ectopically expressed human SRY (hSRY) on gene expression in the mouse heart. We hypothesize that aberrant expression of the human SRY gene could affect the development and physiology of transgenic mice. To test this hypothesis we have established a Cre-LoxP transgene activation system, thereby activating and expressing the hSRY transgene at the single-cell embryonic stage. Such transgenic mice were born of similar sizes as non-transgenic littermates, but retard in postnatal growth and all die within two weeks of age. To determine the molecular changes associated with such phenotypes, we have analyzed the transcriptomes of hearts of pups expressing (hSRY-ON) and not-expressing (hSRY-OFF) the hSRY transgene. The results provide important information demonstrating that ectopic expression of hSRY resulted in altered expression patterns of numerous genes associating with the development of cardiovascular system and pathogenesis of cardiovascular diseases in the heart.

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Genome-wide analysis of the altered gene expression in the transgenic mice ectopically expressing the human SRY. [brain]

Project description:Analysis of the effects of an ectopically expressed human SRY (hSRY) on gene expression in the mouse brain. We hypothesize that aberrant expression of the human SRY gene could affect the development and physiology of transgenic mice. To test this hypothesis we have established a Cre-LoxP transgene activation system, thereby activating and expressing the hSRY transgene at the single-cell embryonic stage. Such transgenic mice were born of similar sizes as non-transgenic littermates, but retard in postnatal growth and all die within two weeks of age. To determine the molecular changes associated with such phenotypes, we have analyzed the transcriptomes of brains of pups expressing (hSRY-ON) and not-expressing (hSRY-OFF) the hSRY transgene. The results provide important information demonstrating that ectopic expression of hSRY resulted in altered expression patterns of numerous genes associating with the development the nervous system and pathogenesis of neurological diseases in the brain.

2017-04-16 | GSE97843 | GEO

Genome-wide analysis of the altered gene expression in the transgenic mice ectopically expressing the human SRY. [liver]

Project description:Analysis of the effects of an ectopically expressed human SRY (hSRY) on gene expression in the mouse liver. We hypothesize that aberrant expression of the human SRY gene could affect the development and physiology of transgenic mice. To test this hypothesis we have established a Cre-LoxP transgene activation system, thereby activating and expressing the hSRY transgene at the single-cell embryonic stage. Such transgenic mice were born of similar sizes as non-transgenic littermates, but retard in postnatal growth and all die within two weeks of age. To determine the molecular changes associated with such phenotypes, we have analyzed the transcriptomes of livers of pups expressing (hSRY-ON) and not-expressing (hSRY-OFF) the hSRY transgene. The results provide important information demonstrating that ectopic expression of hSRY resulted in altered expression patterns of numerous genes associating with the development of hepatic system and pathogenesis of hepatic system diseases in the liver.

2017-04-16 | GSE97846 | GEO

Mus musculus

Project description:Genome-wide analysis of the altered gene expression in the transgenic mice ectopically expressing the human SRY. [brain]

| PRJNA383043 | ENA

Mus musculus

Project description:Genome-wide analysis of the altered gene expression in the transgenic mice ectopically expressing the human SRY. [liver]

| PRJNA383044 | ENA

Mus musculus

Project description:Genome-wide analysis of the altered gene expression in the transgenic mice ectopically expressing the human SRY. [lung]

| PRJNA383041 | ENA

Mus musculus

Project description:Genome-wide analysis of the altered gene expression in the transgenic mice ectopically expressing the human SRY. [heart]

| PRJNA383042 | ENA

Transcription profiling time series of Drosophila embryos expressing bagpipe ectopically in the mesoderm

Project description:Expression profiling of D. melanogaster embryos expressing bagpipe ectopically in the mesoderm, measured in a timecourse of embryogenesis. Three one-hour timepoints were assayed (3.5-4.5, 4.5-5.5, 5.5-6.5 hrs after egg laying). Homozygous ectopically expressing embryos were collected using from a large scale cross of UAS-bin and twist-Gal4, 24B-Gal4 flies, in parallel to stage-matched controls. Four independent collections were performed at each timepoint. Total RNA was extracted and amplified. Ectopically expression and respective reference samples were hybridized together on INDAC oligo-arrays.

2007-10-11 | E-TABM-248 | biostudies-arrayexpress

Transcription profiling time series of Drosophila embryos expressing biniou ectopically in the mesoderm

Project description:Expression profiling of D. melanogaster embryos expressing biniou ectopically in the mesoderm, measured in a timecourse of embryogenesis. Three one-hour timepoints were assayed (4-5, 5-6, 6-7 hrs after egg laying). Homozygous ectopically expressing embryos were collected using from a large scale cross of UAS-bin and twist-Gal4, 24B-Gal4 flies, in parallel to stage-matched controls. Four independent collections were performed at each timepoint. Total RNA was extracted and amplified. Ectopically expression and respective reference samples were hybridized together on INDAC oligo-arrays.

2007-10-11 | E-TABM-251 | biostudies-arrayexpress

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