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Homo sapiens

ABSTRACT: Retinoic acid suppresses MYB in adenoid cystic carcinoma [ChIP-seq]

PROVIDER: PRJNA383656 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5460840.fastq.gz	Fastqsanger.gz
	SRR5460850.fastq.gz	Fastqsanger.gz
	SRR5460841.fastq.gz	Fastqsanger.gz
	SRR5460851.fastq.gz	Fastqsanger.gz
	SRR5460842.fastq.gz	Fastqsanger.gz

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Homo sapiens

Project description:Retinoic acid suppresses MYB in adenoid cystic carcinoma [RNA-seq]

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Retinoic acid suppresses MYB in adenoid cystic carcinoma

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Retinoic acid suppresses MYB in adenoid cystic carcinoma [RNA-seq]

Project description:Translocations that drive overexpression of the oncogenic transcription factor MYB are molecular hallmarks of adenoid cystic carcinoma (ACC), a malignant salivary gland tumor. Surgical resection, whenever possible, is the standard therapy for ACC, but there are no available therapeutic options available if surgery fails. Here we performed a chemical genetic screen using a zebrafish embryo culture system and identified retinoic acid agonists as potent suppressors of c-myb. Retinoic acid treatment strongly decreased c-myb gene expression in U937 cells and suggested a direct transcriptional mechanism of regulation. Retinoic acid agonists strongly inhibited tumor growth in vivo in different ACC patient derived xenograft models. Analysis of the xenografts revealed a significant decrease in MYB binding at translocated enhancers, thereby disrupting the MYB positive feedback loop that drives ACC. Our findings identify an important role of retinoic acid in MYB regulation and as a potential new effective therapy for ACC.

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Retinoic acid suppresses MYB in adenoid cystic carcinoma [ChIP-seq]

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ChIP-seq of MYB in adenoid cystic carcinoma (ACC) ACCX11 cells

Project description:Chromatin immunoprecipitation was carried out using an anti-MYB antibody in PDX-derived ACCX11 adenoid cystic carcinoma cells. Input samples were extracted prior to the addition of antibody.

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Project description:ChIP-seq of MYB in adenoid cystic carcinoma (ACC) ACCX11 cells

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Gene expression profile at single cell level of a rare seen and young tracheal adenoid cystic carcinoma

Project description:tracheal adenoid cystic carcinoma is one kind of non-small-cell lung cancer with limit treatment options. We used single cell RNA sequencing (scRNA-seq) to analyze the molecular characteristic of tracheal adenoid cystic carcinoma, aiming to recognized this disease deeply and provide potential treatment plan in the future.

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Project description:An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma

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