Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Organismal sensitivity to environmental agents induced toxicity: A comparative ecotoxicogenomics approach

ABSTRACT: Organismal sensitivity to environmental agents induced toxicity: A comparative ecotoxicogenomics approach

PROVIDER: PRJNA384181 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Organismal sensitivity to environmental agents induced toxicity: A comparative ecotoxicogenomics approach [Drosophila]

Project description:To understand the role of genetic makeup in organismal tolerance/susceptibility we compared the Caenorhabditis elegans transcriptome profiles with those of Drosophila melanogaster. In this study, we exposed both organisms, to a synthetic chemical and evaluated their response at the transcriptome level, to gain insights to molecular players/pathways underlying organismal tolerance/susceptibility to xenobiotics

2018-12-01 | GSE98164 | GEO

Organismal sensitivity to environmental agents induced toxicity: A comparative ecotoxicogenomics approach [Caenorhabditis elegans]

2018-12-01 | GSE98165 | GEO

Organismal sensitivity to environmental agents induced toxicity: A comparative ecotoxicogenomics approach

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-12-01 | GSE98166 | GEO

Drosophila melanogaster

Project description:Organismal sensitivity to environmental agents induced toxicity: A comparative ecotoxicogenomics approach [Drosophila]

| PRJNA384195 | ENA

Caenorhabditis elegans

Project description:Organismal sensitivity to environmental agents induced toxicity: A comparative ecotoxicogenomics approach [Caenorhabditis elegans]

| PRJNA384194 | ENA

organismal metagenomes

Project description:organismal metagenomes Raw sequence reads

| PRJNA756623 | ENA

organismal metagenomes

Project description:organismal metagenomes Raw sequence reads

| PRJNA473282 | ENA

Thrombopoietic Agents: Novel Osteoinductive Agents for Bone Healing

Project description:Thrombopoietic Agents: Novel Osteoinductive Agents for Bone Healing

| PRJNA627964 | ENA

Transcription profiling of rat intestinal epithelial IEC-6 cells treated with non-steroidal anti-inflammatory agents to investigate gastrointestinal toxicity of NSAIDs

Project description:Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively as therapeutic agents, despite their well-documented gastrointestinal (GI) toxicity. Presently, the mechanisms responsible for NSAID-associated GI damage are incompletely understood. In this study, we used Microarray analysis to generate a novel hypothesis about cellular mechanisms that underlie the GI toxicity of NSAIDs. Monolayers of intestinal epithelial; cells (IEC-6) were treated with NSAIDs that either exhibit indomethacin, NS-398) or lack (SC-560) inhibitory effects on intestinal epithelial cell migration. Bioinformatic analysis of array data suggested that NSAIDs with adverse GI effects either decrease the gene expression of the calpains or increase the gene expression of the calpain engodenous; inhibitor, calpastatin. Calpains have been shown previously to modulate the migration of a variety of cells in different physiological contexts. Our experimental results suggest that the altered expression of calpain genes may contribute to the adverse effects of NSAIDs on intestinal; epithelial restitution. Microarray analysis has generated the novel hypothesis that the GI toxicity of NSAIDs may be attributed in part to drug-induced changes in the expression and activity of calpains. Experiment Overall Design: Monolayers of intestinal epithelial cells (IEC-6) were treated with NSAIDs that either exhibit (indomethacin, NS-398) or lack (SC-560) inhibitory effects on intestinal epithelial cell migration. Samples were then pooled to obtain sufficient material for gene array analysis. The pooled samples were used to hybridize 4 gene array chips for each biological sample.

2009-03-27 | E-GEOD-7584 | biostudies-arrayexpress

Benzene toxicity

Project description:Benzene toxicity

| PRJNA641636 | ENA