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Homo sapiens

ABSTRACT: Expression profile of Gastro-Entero-Pancreatic Neuroendocrine Tumors (GEP-NET)

PROVIDER: PRJNA386518 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5553770.fastq.gz	Fastqsanger.gz
	SRR5553780.fastq.gz	Fastqsanger.gz
	SRR5553790.fastq.gz	Fastqsanger.gz
	SRR5553800.fastq.gz	Fastqsanger.gz
	SRR5553810.fastq.gz	Fastqsanger.gz

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Project description:Solid-pseudopapillary neoplasm of pancreas(SPN), ductal adenocarcinoma(PCA), neuroendocrine tumor(NET) and non-neoplastic pancreas. To investigate the specific gene expression of SPN compared to other types of pancreatic tumor, we analyzed large-scale gene expressioin analysis to identify the molecular signature that may affect SPN tumorigenesis. Differentially expressed genes were analyzed on SPNs, PCAs, NETs and Non-neoplastic tissues. Solid-pseudopapillary neoplasm (SPN) is an uncommon pancreatic tumor with distinct clinicopathologic features. SPNs are characterized by mutations in exon 3 of CTNNB1. However, little is known about the gene and microRNA expression profiles of SPNs. Thus, we sought to characterize SPN-specific gene expression and identify the signaling pathways activated in these tumors. The mRNA expression profile of 14 SPNs, 6 pancreatic adenocarcinomas (PCAs), 6 pancreatic neuroendocrine tumors (NETs), and five non-neoplastic pancreatic tissues were analyzed.

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