Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: Genome-wide profiling of active regulatory elements in dentate gyrus of WT and MBD1 KO mice

PROVIDER: PRJNA387082 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5572320.fastq.gz	Fastqsanger.gz
	SRR5572321.fastq.gz	Fastqsanger.gz
	SRR5572322.fastq.gz	Fastqsanger.gz
	SRR5572323.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Genome-wide profiling of active regulatory elements in dentate gyrus of WT and MBD1 KO mice

Project description:We report the genome-wide active regulatory elements in mouse dentate gyrus with or without presence of MBD1.

2018-05-15 | GSE99000 | GEO

Genome-wide maps of MBD1 in mouse dentate gyrus

Project description:We report the MBD1 binding profiles in mouse dentate gyrus by sequencing MBD1 chromatin immunoprecipitated DNA

2018-05-15 | GSE98975 | GEO

Mus musculus

Project description:Genome-wide maps of MBD1 in mouse dentate gyrus

| PRJNA387074 | ENA

Medullary Thymic Epitherlial Cell (mTEC) Gene Expression in MBD1 WT and KO Mice

Project description:To explore global gene expression using microarray analysis in mTEC's isolated from MBD1 WT and MBD1 KO mice mTECs were sorted by flow cytometry from 30 day old MBD1 WT and KO Mice. 4 biological replicates were performed for both MBD1 WT and KO mice (1 replicate of each failed quality control and wasd removed from the analysis).

2013-11-21 | E-GEOD-52547 | biostudies-arrayexpress

Medullary Thymic Epitherlial Cell (mTEC) Gene Expression in MBD1 WT and KO Mice

Project description:To explore global gene expression using microarray analysis in mTEC's isolated from MBD1 WT and MBD1 KO mice

2013-11-21 | GSE52547 | GEO

Adult Born Hippocampal Neurons Mount Unique Translational Changes in Response to Voluntary Running

Project description:We report the genome-wide gene expression in adult born hippocampal neurons (at three different stages) in dentate gyrus of volentary running mice

2020-09-02 | GSE142678 | GEO

Transcriptome analysis of single cells from the mouse dentate gyrus [10X]

Project description:RNA sequencing was performed on 5454 single cells from dentate gyrus of CD-1 mice, sampled at postnatal day 12, 16, 24 and 35, with the aim of studying the postnatal dentate gyrus neurogenesis.

2017-12-13 | GSE95315 | GEO

Single-Cell Analysis of Aging Mouse Dentate Gyrus

Project description:The dentate gyrus of the hippocampus is a brain region involved in learning, memory formation, and spatial coding. We performed single-cell RNA-sequencing of the dentate gyrus of young and old mice to identify the age-induced changes.

2023-07-19 | GSE205936 | GEO

Next-generation Sequencing Facilitates Quantitative Analysis of Wild Type and EED cKO mice Hippocampus Dentate Gyrus Transcriptomes

Project description:Purpose:Quantification differentially expressed genes and find target genes. The goals of this study are to compare Wild Type and EED cKO hippocampus dentate gyrus transcriptome profiling (RNA-seq) to quantitative reverse transcription polymerase chain reaction (qRT–PCR) differentially expressed genes and find target genes Methods: Hippocampus dentate gyrus mRNA profiles of 14-day-old wild-type (WT) and Embryonic Ectoderm Development conditional knockout (EED cKO) mice were generated by deep sequencing, in two biological replicates,using BGISEQ-500 platform.All RNA-Seq data were aligned to mouse genome version mm10 using HISAT.We use cluster software and Euclidean distance matrix for the hierarchical clustering analysis of the expressed gene and sample program at the same time, the clustering results can be viewed with javaTreeview. qRT–PCR validation was performed using SYBR Green assays. Results:Only transcripts that showed more than 2-fold differential expression compared to control were subjected to relevance network analysis. 1047 candidate genes that were differentially expressed with biological functional groups as compared between WT and EED cKO mice . Conclusions: Our study represents the first detailed analysis of Wild Type and EED cKO mice hippocampus dentate gyrus transcriptomes, with two biologic replicates, generated by RNA-seq technology.

2019-05-11 | GSE131035 | GEO

Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells

Project description:Immature dentate granule cells (DGCs) generated in the hippocampus during adulthood are believed to play a unique role in dentate gyrus function. Although immature DGCs have hyperexcitable membrane properties in vitro, the consequences of this hyperexcitability in vivo remain unclear. In particular, the relationship between experiences that activate the dentate gyrus, such as exploration of a novel environment (NE), and downstream molecular processes that modify dentate gyrus circuitry in response to cellular activation are unknown in this cell population. We first performed quantification of immediate early gene proteins in immature (5-week-old) and mature (13-week-old) DGCs from mice exposed to a NE. Paradoxically, we observed lower immediate early gene protein expression in hyperexcitable immature DGCs. We then isolated nuclei from active and inactive immature DGCs and performed single nuclei RNA-Sequencing. Compared to mature nuclei collected from the same animal, immature DGC nuclei showed less activity-induced transcriptional change, even though they were classified as active based on expression of ARC protein. These results demonstrate that the coupling of spatial exploration, cellular activation, and transcriptional change differs between immature and mature DGCs, with blunted activity-induced changes in immature cells.

2023-02-23 | GSE214309 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data