Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens strain:K562

ABSTRACT: MPRA libraries in K562 cells

PROVIDER: PRJNA389101 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5651570.fastq.gz	Fastqsanger.gz
	SRR5651571.fastq.gz	Fastqsanger.gz
	SRR5651572.fastq.gz	Fastqsanger.gz
	SRR5651569.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Homo sapiens strain:K562

Project description:PatchMPRA from K562 cells

| PRJNA394868 | ENA

Homo sapiens strain:K562 cells

Project description:MLV integration sites in human K562 cells

| PRJNA188712 | ENA

Homo sapiens strain:K562 cells

Project description:RNAseq analysis of NOX2/NOX4 interfered K562 cells

| PRJNA928236 | ENA

Homo sapiens strain:K562

Project description:ChIP-seq analysis for RNA polymerase II distribution in DDX41-knockdown K562 cells

| PRJDB13680 | ENA

Homo sapiens strain:K562

Project description:Homo sapiens strain:K562 Raw sequence reads

| PRJNA645615 | ENA

Molecular mechanism of EPC1-PHF1 fusion protein (ChIP-seq Homo Sapiens)

Project description:In this study, we characterize the fusion protein produced by the EPC1-PHF1 translocation in Low Grade Endometrial Stromal Sarcoma (LG-ESS) and Ossifying FibroMyxoid Tumors (OFMT). We express the fusion protein and necessary controls in K562 Cells. The fusion protein assembles a mega-complex harboring both NuA4/TIP60 and PRC2 subunits and enzymatic activities and leads to mislocalization of chromatin marks in the genome, linked to aberrant gene expression.

2020-11-25 | GSE162118 | GEO

Homo sapiens strain:K562

Project description:Homo sapiens strain:K562 Transcriptome or Gene expression

| PRJNA233564 | ENA

Homo sapiens strain:K562

Project description:Homo sapiens strain:K562 Transcriptome or Gene expression

| PRJNA238846 | ENA

Homo sapiens foetal mesenchymal stem cell miRNA transcriptome

Project description:We have sequenced miRNA libraries from human embryonic, neural and foetal mesenchymal stem cells. We report that the majority of miRNA genes encode mature isomers that vary in size by one or more bases at the 3’ and/or 5’ end of the miRNA. Northern blotting for individual miRNAs showed that the proportions of isomiRs expressed by a single miRNA gene often differ between cell and tissue types. IsomiRs were readily co-immunoprecipitated with Argonaute proteins in vivo and were active in luciferase assays, indicating that they are functional. Bioinformatics analysis predicts substantial differences in targeting between miRNAs with minor 5’ differences and in support of this we report that a 5’ isomiR-9-1 gained the ability to inhibit the expression of DNMT3B and NCAM2 but lost the ability to inhibit CDH1 in vitro. This result was confirmed by the use of isomiR-specific sponges. Our analysis of the miRGator database indicates that a small percentage of human miRNA genes express isomiRs as the dominant transcript in certain cell types and analysis of miRBase shows that 5’ isomiRs have replaced canonical miRNAs many times during evolution. This strongly indicates that isomiRs are of functional importance and have contributed to the evolution of miRNA genes

2014-08-06 | GSE58734 | GEO