Project description:Deep sequencing of mRNA from Pteropus alecto and Myotis davidii Analysis of ploy(A)+ RNA of Pteropus alecto and Myotis davidii

2012-12-18 | E-GEOD-39933 | biostudies-arrayexpress

Pteropus alecto strain:Gouldii

Project description:Pteropus alecto basal Transcriptome

| PRJNA512034 | ENA

Molecular characterisation of Toll-like receptors in the black flying fox Pteropus alecto.

Project description:Bats are believed to be reservoir hosts for a number of emerging and re-emerging viruses, many of which are responsible for illness and mortality in humans, livestock and other animals. In other vertebrates, early responses to viral infection involve engagement of Toll-like receptors (TLRs), which induce changes in gene expression collectively leading to an "antiviral state". In this study we report the cloning and bioinformatic analysis of a complete set of TLRs from the black flying fox Pteropus alecto, and perform quantitative tissue expression analysis of the nucleic acid-sensing TLRs 3, 7, 8 and 9. Full-length mRNA transcripts from TLRs homologous to human TLRs 1-10 were sequenced, as well as a nearly intact TLR13 pseudogene that was spliced and polyadenylated. This prototype data can now be used to design functional studies of the bat innate immune system.

| S-EPMC7103217 | biostudies-literature

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