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Human reproductive system metagenome

ABSTRACT: Microbiota in endometrial fluid and tissue of IVF-ET patients

PROVIDER: PRJNA391382 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5748040_1.fastq.gz	Fastqsanger.gz
	SRR5748040_2.fastq.gz	Fastqsanger.gz
	SRR5748041_1.fastq.gz	Fastqsanger.gz
	SRR5748041_2.fastq.gz	Fastqsanger.gz
	SRR5748042_1.fastq.gz	Fastqsanger.gz

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human metagenome [Taxonomy ID: 646099]

Project description:Microbiota in endometrial fluid and tissue of IVF-ET patients

| PRJNA438172 | ENA

Study on VEGF regulation mechanism of acupuncture improving endometrial receptivity in IVF-ET

Project description:We find that the Endometrial Blood Vessel Generation is an important part ofthe establishment of Endometrial Receptivity. We have demonstrated inprevious experiments: Acupuncture in IVF-ET treatment can effectively improve Endometrial Receptivity and improve the pregnancy rate, therefore, we proposea VEGF signaling pathway in Acupuncture can improve Endometrial receptivity, thus improving the success rate of IVF-ET Hypothesis. Around the hypothesisintends to adopt the rat model of IVF-ET, through methods of acupuncture, acupuncture combined with blocker, research the related indexes effect performance that acupuncture on the VEGF signaling pathway in endometrial. Using experimental techniques such as Morphological observation, ELIAS, Immunohistochemistry, Real-time quantitative PCR, Methylation-sensitive high-resolution melting curve method(MS-HRM), to complete the research ofobserving the Effect of acupuncture interference IVF-ET, Blocking the impaction VEGF to the effect, the relationship VEGF or gene methylation inits receptors with effect. From the molecular level clarify the adverse effects and mechanism action that acupuncture will improve IVF-ET superovulation of endometrial receptivity, through adjust VEGF signaling pathway, to provide a scientific basis for acupuncture in IVF-ET treatment

2021-12-09 | GSE190472 | GEO

human reproductive system metagenome

Project description:16S rRNA gene amplicon sequencing of endometrial cancer-associated bacteria

| PRJNA481576 | ENA

Screening and identification of endometrium proteins as novel potential biomarkers

Project description:After more than 40 years, IVF technology has made rapid progress. However, the clinical pregnancy rate remained around 33.8-42.7%. After the implementation of blastocyst transplantation, the clinical pregnancy rate increased to 60.4%. One of the key factors affecting the pregnancy rate of IVF is the RIF, actually the poor endometrial receptivity is the main reason for the decrease of pregnancy possibility in RIF patients. In our study, the endometriumof IVF-ET patients during WOI was collected and divided into RIF group and pregnant controls group according to pregnancy outcomes. Specific proteins related to endometrial receptivity were screened by iTRAQ-2D LC-MS/MS.

2020-08-22 | PXD021068 |

Gene expression study of human endometrial receptivity in IVF implantation failure patients undergoing ovarian stimulation

Project description:Endometrial receptivity on genomic level is one of the major cause of implantation failure in IVF patients with unexlained infertility and is a main obstacle in success of IVF. Gene expression profiles of implantation failure cases of unexplained infertility were compared with proven healthy oocyte donors as controls, both undergoing ovarian stimulation. The results provide additional information about gene expression profile related to endometrial receptivity in implantation failure cases especially under the influence of ovarian stimulation during IVF cycle.

2018-08-07 | GSE71835 | GEO

Gene expression study of human endometrial receptivity in IVF implantation failure patients undergoing ovarian stimulation II

Project description:Endometrial receptivity on genomic level is one of the major cause of implantation failure in IVF patients with unexplained infertility and is a main obstacle in success of IVF. Gene expression profiles of implantation failure cases of unexplained infertility were compared with proven healthy oocyte donors as controls, both undergoing ovarian stimulation. The results provide additional information about gene expression profile related to endometrial receptivity in implantation failure cases especially under the influence of ovarian stimulation during IVF cycle.

2019-06-25 | GSE92324 | GEO

human reproductive system metagenome

Project description:cervical microbiota Raw sequence reads

| PRJNA320048 | ENA

human reproductive system metagenome

Project description:Effect of sex on oral and genital microbiota

| PRJNA524629 | ENA

COX-2 network as predictive molecular marker for clinical pregnancy in IVF

Project description:CONTEXT Nowadays, the molecular mechanisms involved in endometrial receptivity and implantation are still not clear. OBJECTIVE The gene expression of human endometrium of patients undergoing an IVF treatment with GnRH antagonists/rec-FSH was studied. CONCLUSIONS COX-2 has been extensively studied as a crucial fertility element in both knock-out mice and human. It appears that increased expression of COX-2 and/or SCGB1D2 on the day of oocyte retrieval in GnRH antagonist/rec-FSH stimulated cycles coincides with a lower probability of achieving a clinical pregnancy in this cycle. Keywords: gene expression analysis, clinical pregnancy in IVF stimulated cycles Endometrial biopsies taken from patients on day of oocyte retrieval in stimulated IVF cycles with 1 or 2 embryos replaced in the same cycle. Gene expression of pregnant patients (n=4) was compared with matched non-pregnant patients (n=4)

2010-09-06 | E-GEOD-18140 | biostudies-arrayexpress

Integrated Analysis of Hub Genes and MicroRNAs in Human Placental Tissues from In Vitro Fertilization-Embryo Transfer [RNA-seq]

Project description:Next generation sequencing was perfomed to identify differentially expressed gene in Placental tissue samples from IVF-ET assisted or natural conceived pregnancies

2021-10-21 | GSE186147 | GEO

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