Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies

ABSTRACT: Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies

PROVIDER: PRJNA391729 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies VII

Project description:Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. Conclusion: Antibodies to GD2 evolved from highly specific germlines. Highly specific germlines may be critical in evading autoimmunity issues.

2017-08-25 | GSE100310 | GEO

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies VI

2017-08-25 | GSE100309 | GEO

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies V

2017-08-25 | GSE100308 | GEO

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies IV

2017-08-25 | GSE100307 | GEO

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies III

2017-08-25 | GSE99874 | GEO

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies II

2017-08-25 | GSE99873 | GEO

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies I