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Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies V

ABSTRACT: Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies V

PROVIDER: PRJNA391737 | ENA |

REPOSITORIES: ENA

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Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies VI

Project description:Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. Conclusion: Antibodies to GD2 evolved from highly specific germlines. Highly specific germlines may be critical in evading autoimmunity issues.

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