Project description:Transcriptional profiling of dorsolateral prostate of mice with prostate-specific transgenic expression of miR-32 compared with wild type mice.
Project description:Transcriptional profiling of ventral prostate of mice with prostate-specific transgenic expression of miR-32 compared with wild type mice.
Project description:We compare the overall gene expression of transgenic mice expressing the MYC oncogene (hiMYC mice) to induce tumorigenesis in the mouse prostate with mice having transgenic expression of the microRNA miR-32 in hiMYC background to determine whether increased expression of miR-32 influences growth or phenotype in prostate adenocarcinoma in vivo.
Project description:Gene expression profile of Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) reveals murine targets for preclinical development of human prostate cancer therapy; In this study, we have generated an open source TRAMP microarray dataset to identify differentially expressed genes from human prostate cancer that have concordant expression in TRAMP tumors, and thereby represent lead targets for preclinical therapy development. Affymetrix Mouse 430 2.0 chips were used for microarrays of total RNA from 9 TRAMP tumors and 9 normal prostates (ventral and dorsolateral lobes). Experiment Overall Design: normal prostate vs. TRAMP
Project description:Gene expression profile of Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) reveals murine targets for preclinical development of human prostate cancer therapy In this study, we have generated an open source TRAMP microarray dataset to identify differentially expressed genes from human prostate cancer that have concordant expression in TRAMP tumors, and thereby represent lead targets for preclinical therapy development. Affymetrix Mouse 430 2.0 chips were used for microarrays of total RNA from 9 TRAMP tumors and 9 normal prostates (ventral and dorsolateral lobes). Keywords: prostate cancer, TRAMP
Project description:The gene expression profling between Control and apocynin 500 mg/L treatment in ventral prostate lobe of Transgenic Rat for Adenocarcinoma of Prostate (TRAP) rats
Project description:The gene expression profling between Control and apocynin 500 mg/L treatment in ventral prostate lobe of Transgenic Rat for Adenocarcinoma of Prostate (TRAP) rats Two-condition experiment, Control vs. apocynin treatment. Biological replicates: 3 control rats, 3 apocynin-treated rats. Mixed 3 samples from each group on one array