Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Drosophila melanogaster

ABSTRACT: Polycomb Repressive Complex 1 regulates transcription of active genes [NTseq]

PROVIDER: PRJNA392101 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5760670.fastq.gz	Fastqsanger.gz
	SRR5760671.fastq.gz	Fastqsanger.gz
	SRR5760672.fastq.gz	Fastqsanger.gz
	SRR5760673.fastq.gz	Fastqsanger.gz
	SRR5760674.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 10

Similar Datasets

Drosophila melanogaster

Project description:Polycomb Repressive Complex 1 regulates transcription of active genes [ChIPseq]

| PRJNA392099 | ENA

Drosophila melanogaster

Project description:Polycomb Repressive Complex 1 regulates transcription of active genes [RNAseq]

| PRJNA392100 | ENA

Polycomb Repressive Complex 1 regulates transcription of active genes

Project description:Polycomb Repressive Complex 1 regulates transcription of active genes

| PRJNA392088 | ENA

Drosophila melanogaster

Project description:Protein interactions within PLEIOHOMEOTIC-repressive complex are critical for its recruitment to Polycomb target genes (Fruit Fly)

| PRJNA178658 | ENA

LFQMS of RING2 (RING1B, RNF2) immunoprecipitation from MDA-MB-231 and T47D breast cancer cells

Project description:Polycomb repressive complex PRC1 is essential for gene regulation in numerous cell fate decisions. We show that RING1B (RING2, RNF2) and canonical PRC1 (cPRC1) genes are amplified and overexpressed in breast cancer (BC). Moreover, cPRC1 complexes functionally associate with genes regulated by cell type specific key transcription factors such as estrogen receptor (ER) in ER+ tumor cells and BRD4 in triple negative BC cells. cPRC1 is recruited to active enhancers in a manner independent of PRC2 and RING1B enzymatic activity. RING1B regulates enhancer activity and gene transcription not only by promoting the expression of BC oncogenes but also by regulating chromatin accessibility for oncogenic transcription factors. RING1B recruitment, and thus PRC1 association, to active enhancers occurs in multiple cancers.

2018-10-19 | PXD009570 | Pride

Drosophila melanogaster

Project description:Cohesin and Polycomb proteins functionally interact to control transcription at silenced, restrained, and active genes [tiling array data]

| PRJNA179166 | ENA

Drosophila melanogaster

Project description:Cohesin and Polycomb proteins functionally interact to control transcription at silenced, restrained, and active genes [expression array data]

| PRJNA179167 | ENA

Cohesin and Polycomb proteins functionally interact to control transcription at silenced, restrained, and active genes [tiling array data]

Project description:Cohesin is crucial for proper chromosome segregation, but also regulates gene transcription and organism development by poorly understood mechanisms. We find that in Drosophila, cohesin functionally interacts with Polycomb group (PcG) silencing proteins at both silenced and active genes. Cohesin unexpectedly facilitates binding of Polycomb Repressive Complex 1 (PRC1) to many active genes. In contrast, cohesin and PRC1 binding are mutually antagonistic at silenced genes. PRC1 depletion decreases phosphorylated RNA polymerase and mRNA at many active genes, but increases them at silenced genes. Cohesin also facilitates long-range interactions between Polycomb Response Elements in the invected-engrailed gene complex where it represses transcription. These multiple distinct cohesin-PcG interactions reveal a previously unrecognized role for PRC1 in facilitating productive gene transcription, and provide new insights into how cohesin and PRC1 control development.

2013-04-25 | GSE42104 | GEO

Drosophila melanogaster

Project description:Polycomb repressive complex 2-dependent and –independent functions of Jarid2 in transcriptional regulation in Drosophila [Affymetrix]

| PRJNA155737 | ENA