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Pseudogymnoascus destructans

ABSTRACT: Causative agent of the White-Nose Syndrome cutaneous infection, a new species of Geomyces

PROVIDER: PRJNA39271 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
		Other
	SRR029259.fastq.gz	Fastqsanger.gz
	SRR029260.fastq.gz	Fastqsanger.gz
	SRR029261.fastq.gz	Fastqsanger.gz
	SRR031784.fastq.gz	Fastqsanger.gz

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Pseudogymnoascus destructans

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Pseudogymnoascus destructans

Project description:Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America With No Sign of Recombination

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P. destructans secretome analyses

Project description:This data is in support of a study entitled "Characterization of PdCP1, a Serine Carboxypeptidase from P. destructans, the Causal Agent of White-nose Syndrome" by Beekman, C. et al. which is submitted and under review. Data will be released upon acceptance of the publication.

2018-04-30 | MSV000082319 | MassIVE

Collagen-Degrading Peptidase Destructin-1

Project description:This dataset is provided in support of the identification of a collagen-degrading enzyme secreted by the fungus P. destructans. P. destructans is responsible for the disease white nose syndrome, which has infected and killed millions of North American bats. Our manuscript, titled "Destructin-1 is a Collagen-Degrading Endopeptidase Secreted by P. destructans, the Causative Agent of White-Nose Syndrome", is under review, and the data set will be released upon acceptance.

2015-03-23 | MSV000079085 | MassIVE

destructin-1 related files

Project description:This is a training data set for destructin-1 protease digestion of a synthetic peptide library for substrate specificity profiling. Data is related to the following publication: O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ. "Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome." Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7478-83. doi: 10.1073/pnas.1507082112. Epub 2015 May 5. Erratum in: Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):E3152. PMCID: PMC4475985.

2015-11-24 | MSV000079388 | MassIVE

Pseudogymnoascus destructans

Project description:Resequencing of North American isolates of Pseudogymnoascus destructans

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Pseudogymnoascus destructans

Project description:Pseudogymnoascus destructans Raw sequence reads

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Pseudogymnoascus destructans

Project description:Pseudogymnoascus destructans Raw sequence reads

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Project description:Transcriptome response to white-nose syndrome varies among bat species

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Pseudogymnoascus destructans transcriptome changes during white-nose syndrome infections.

Project description:White nose syndrome (WNS) is caused by the psychrophilic fungus Pseudogymnoascus destructans that can grow in the environment saprotrophically or parasitically by infecting hibernating bats. Infections are pathological in many species of North American bats, disrupting hibernation and causing mortality. To determine what fungal pathways are involved in infection of living tissue, we examined fungal gene expression using RNA-Seq. We compared P. destructans gene expression when grown in culture to that during infection of a North American bat species, Myotis lucifugus, that shows high WNS mortality. Cultured P. destructans was grown at 10 to 14 C and P. destructans growing in vivo was presumably exposed to temperatures ranging from 4 to 8 C during torpor and up to 37 C during periodic arousals. We found that when P. destructans is causing WNS, the most significant differentially expressed genes were involved in heat shock responses, cell wall remodeling, and micronutrient acquisition. These results indicate that this fungal pathogen responds to host-pathogen interactions by regulating gene expression in ways that may contribute to evasion of host responses. Alterations in fungal cell wall structures could allow P. destructans to avoid detection by host pattern recognition receptors and antibody responses. This study has also identified several fungal pathways upregulated during WNS infection that may be candidates for mitigating infection pathology. By identifying host-specific pathogen responses, these observations have important implications for host-pathogen evolutionary relationships in WNS and other fungal diseases.

| S-EPMC5810475 | biostudies-literature

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