Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Danio rerio

ABSTRACT: Primary spinal OPC culture system from adult zebrafish to study oligodendrocyte differentiation in vitro

PROVIDER: PRJNA393181 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5805890.fastq.gz	Fastqsanger.gz
	SRR5805900.fastq.gz	Fastqsanger.gz
	SRR5805910.fastq.gz	Fastqsanger.gz
	SRR5805891.fastq.gz	Fastqsanger.gz
	SRR5805901.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 30

Similar Datasets

Danio rerio

Project description:RNA sequencing of adult zebrafish spinal cord

| PRJNA309293 | ENA

Danio rerio

Project description:Identification of axonal regeneration-associated genes after spinal cord injury in adult zebrafish

| PRJNA244761 | ENA

Danio rerio

Project description:Adult zebrafish: cornea vs epidermis

| PRJNA133591 | ENA

Danio rerio

Project description:Adult zebrafish: cornea vs dermis

| PRJNA133589 | ENA

Danio spinal cord injury

Project description:Adult zebrafish have the ability to recover from spinal cord injury and exhibit re-growth of descending axons from the brainstem to the spinal cord. We performed gene expression analysis using microarray to find damage-induced genes after spinal cord injury, which shows that Sox11b mRNA is up-regulated at 11 days after injury. However, the functional relevance of Sox11b for regeneration is not known. Here, we report that the up-regulation of Sox11b mRNA after spinal cord injury is mainly localized in ependymal cells lining the central canal and in newly differentiating neuronal precursors or immature neurons. Using an in vivo morpholino-based gene knockout approach, we demonstrate that Sox11b is essential for locomotor recovery after spinal cord injury. In the injured spinal cord, expression of the neural stem cell associated gene, Nestin, and the proneural gene Ascl1a (Mash1a), which are involved in the self-renewal and cell fate specification of endogenous neural stem cells, respectively, is regulated by Sox11b. Our data indicate that Sox11b promotes neuronal determination of endogenous stem cells and regenerative neurogenesis after spinal cord injury in the adult zebrafish. Enhancing Sox11b expression to promote proliferation and neurogenic determination of endogenous neural stem cells after injury may be a promising strategy in restorative therapy after spinal cord injury in mammals. Spinal cord injury or control sham injury was performed on adult zebrafish. After 4, 12, or 264 hrs, a 5 mm segment of spinal cord was dissected and processed (as a pool from 5 animals) in three replicate groups for each time point and treatment.

2010-10-19 | E-GEOD-20460 | biostudies-arrayexpress

Danio rerio

Project description:Single-cell RNA sequencing of zebrafish spinal cord

| PRJNA722570 | ENA

Danio rerio

Project description:NMLF response to spinal cord injury in Zebrafish

| PRJNA139209 | ENA

Danio rerio

Project description:RNA sequencing of adult zebrafish optic tectum

| PRJNA668620 | ENA

Danio rerio

Project description:Mycobacterium marinum chronic infection of adult zebrafish

| PRJNA112215 | ENA

Inflammatory stimulation of zebrafish (Danio rerio) tissues using lipopolisaccharyde.

Project description:We analyzed if genomic responses of adult zebrafish tissues can reproduce the mammalian known inflammatory process induced by acute endotoxin stress. Although the strength of the inflammatory process was influenced by tissue nature, gene regulation was well conserved across evolution and zebrafish genomic responses highly correlated with mammals’ inflammatory reactions after lipopolysaccharide stimulation.

2016-09-18 | GSE73223 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data