Project description:The biological process of RNA translation is fundamental to cellular life and has wide-ranging implications for human disease. Yet, accurately delineating the variation in RNA translation represents a significant challenge. Here, we develop RiboTIE, a transformer model-based approach to map global RNA translation. We find that RiboTIE offers unparalleled precision and sensitivity for ribosome profiling data. Application of RiboTIE to normal brain and medulloblastoma cancer samples enables high-resolution insights into disease regulation of RNA translation.

2024-12-13 | PXD055854 | Pride

Genetics Education: Preparing Physicians for the Future

Project description:This study examines the best way to teach genetics to family medicine residents. First year family medicine residents at the University of Toronto will be taught basic clinical genetics as well as a specific disease in genetics via 3 different educational methods. All participants will undergo an oral examination and written knowledge test 3 months after this education. Results between groups will be compared, and the best way to teach genetics to residents determined.

| 2030694 | ecrin-mdr-crc

Genetic and Environmental interactions contribute to immune variation in rewilded mice

Project description:The relative and synergistic contributions of genetics and environment to inter-individual immune response variation remain unclear, despite its implications for understanding both evolutionary biology and medicine. We used single cell RNA sequencing (scRNA-seq) to quantify the interactive effects of genotype and environment on immune traits by investigating three inbred mouse sttrain rewilded in an outdoor enclosure and infected with the parasite, Trichuris muris

2024-04-29 | GSE236347 | GEO

Therapeutic genetics and disease modeling in LAMA2-CMD

Project description:Therapeutic genetics and disease modeling in LAMA2-CMD

| PRJNA951468 | ENA

Therapeutic genetics and disease modeling in LAMA2-CMD

Project description:Therapeutic genetics and disease modeling in LAMA2-CMD

| PRJNA951467 | ENA