Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: Rapid chromatin switch in the direct reprogramming of fibroblasts to neurons

PROVIDER: PRJNA394116 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5822260_1.fastq.gz	Fastqsanger.gz
	SRR5822260_2.fastq.gz	Fastqsanger.gz
	SRR5822270_1.fastq.gz	Fastqsanger.gz
	SRR5822270_2.fastq.gz	Fastqsanger.gz
	SRR5822280_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 82

Similar Datasets

Mus musculus

Project description:Rapid conversion of fibroblasts into functional forebrain GABAergic interneurons by direct genetic reprogramming

| PRJNA298895 | ENA

Mus musculus

Project description:Dissecting the direct reprogramming path of fibroblasts into neurons by single cell RNA-sequencing

| PRJNA279486 | ENA

Mus musculus

Project description:Direct Reprogramming of Fibroblasts into a Cardiomimetic Tissue

| PRJNA379178 | ENA

Mus musculus

Project description:Direct Reprogramming of Fibroblasts into Epiblast Stem Cells

| PRJNA125975 | ENA

Mus musculus

Project description:Direct reprogramming of fibroblasts into antigen-presenting dendritic cells

| PRJNA402077 | ENA

Mus musculus

Project description:Single cell analysis of Direct Lineage Reprogramming into Dopaminergic Neurons

| PRJNA1120196 | ENA

Mus musculus

Project description:Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails

| PRJNA287135 | ENA

Mus musculus

Project description:Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors

| PRJNA357260 | ENA

Genome-wide profiling of chromatin accessibility during microRNA-mediated neuronal reprogramming [ATAC-seq]

Project description:Neuronal microRNAs, miR-9/9* and miR-124 (miR-9/9*-124), exert reprogramming activities to direct cell-fate conversion of adult human fibroblasts to post-mitotic neurons and enable the generation of discrete neuronal subtypes with additional transcription factors. Previously, the molecular events underlying the neurogenic switch mediated by microRNAs during neuronal reprogramming were unknown. Here, we systematically dissected the neurogenic state induced by miR-9/9*-124 alone and reveal the surprising capability of miR-9/9*-124 in coordinately stimulating the reconfiguration of chromatin accessibilities, DNA methylation and transcriptome, leading to the generation of functionally excitable neurons, yet unbiased towards a particular subtype-lineage. We show that the microRNA-induced neuronal state enables additional transcription factors, ISL1 and LHX3, to selectively commit conversion to a highly homogenous population of human spinal cord motor neurons. Taken together, our study reveals a modular synergism between microRNAs and transcription factors that allows lineage-specific neuronal reprogramming, providing a platform for generating distinct subtypes of human neurons.

2017-08-04 | GSE102021 | GEO

Bidirectional Introgression between Mus musculus domesticus and Mus spretus.

Project description:Introgressed variants from other species can be an important source of genetic variation because they may arise rapidly, can include multiple mutations on a single haplotype, and have often been pretested by selection in the species of origin. Although introgressed alleles are generally deleterious, several studies have reported introgression as the source of adaptive alleles-including the rodenticide-resistant variant of Vkorc1 that introgressed from Mus spretus into European populations of Mus musculus domesticus. Here, we conducted bidirectional genome scans to characterize introgressed regions into one wild population of M. spretus from Spain and three wild populations of M. m. domesticus from France, Germany, and Iran. Despite the fact that these species show considerable intrinsic postzygotic reproductive isolation, introgression was observed in all individuals, including in the M. musculus reference genome (GRCm38). Mus spretus individuals had a greater proportion of introgression compared with M. m. domesticus, and within M. m. domesticus, the proportion of introgression decreased with geographic distance from the area of sympatry. Introgression was observed on all autosomes for both species, but not on the X-chromosome in M. m. domesticus, consistent with known X-linked hybrid sterility and inviability genes that have been mapped to the M. spretus X-chromosome. Tract lengths were generally short with a few outliers of up to 2.7 Mb. Interestingly, the longest introgressed tracts were in olfactory receptor regions, and introgressed tracts were significantly enriched for olfactory receptor genes in both species, suggesting that introgression may be a source of functional novelty even between species with high barriers to gene flow.

| S-EPMC8784167 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data