Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mice gut microbiome

ABSTRACT: Microbiome from cecum of mice Raw sequence reads

PROVIDER: PRJNA394608 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5832520.fastq.gz	Fastqsanger.gz
	SRR5832530.fastq.gz	Fastqsanger.gz
	SRR5832540.fastq.gz	Fastqsanger.gz
	SRR5832550.fastq.gz	Fastqsanger.gz
	SRR5832560.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 59

Similar Datasets

Raw potato starch alters the cecal microbiome and gene expression in mice fed a Western diet (Cecum)

Project description:We investigated the effect of feeding mice a Total Western Diet formulated using the 50th percentile daily intake levels for macro and micronutrients from the National Health and Nutrition Examination Survey (NHANES) with 0, 2, 5, or 10% added raw potato starch on the cecal microbiome (16S) and cecum, proximal and distal colon gene expression by RNASeq analysis.

2022-04-13 | GSE182456 | GEO

Donor mice gut microbiome

Project description:Donor mice gut microbiome Raw sequence reads

| PRJNA1136793 | ENA

Raw potato starch alters the cecal microbiome and gene expression in mice fed a Western diet (Distal Colon)

2022-04-13 | GSE182457 | GEO

Raw potato starch alters the cecal microbiome and gene expression in mice fed a Western diet (Proximal Colon)

2022-04-13 | GSE182454 | GEO

gut microbiome of ICR mice

Project description:gut microbiome of ICR mice Raw sequence reads

| PRJNA721276 | ENA

Gut microbiome in TRP-KO mice

Project description:Gut microbiome in TRP-KO mice Raw sequence reads

| PRJNA597161 | ENA

The gut microbiome protects genetically predisposed mice against leukemia

Project description:We used microarrays to investigate gene expression changes in leukemic cells from Pax5+/- mice treated with antibiotics. Precursor B cell acute lymphoblastic leukemia (pB-ALL), the most common type of childhood leukemia, is frequently characterized by the cooperation of a genetic predisposition acquired in utero and secondary oncogenic events taking place only in a fraction of predisposed children after birth. Although predisposition can be detected at birth, it is currently unknown which factors determine the development of overt leukemia in genetic carriers and how this can be potentially prevented. Experimental studies have shown that infectious stimuli promote disease onset in genetically predisposed mice. Here, we analyzed the impact of the microbiome on leukemogenesis in a mouse model (Pax5+/- mice) that faithfully mimicks genetic predisposition and leukemogenesis of human pB-ALL related to the synergy of genetic predisposition and exposure to a natural infectious environment. Employing 16S rRNA sequencing and machine learning we can accurately predict a distinct gut microbiome which is determined by a specific constitutional genetic variant. Deprivation of the gut microbiome by antibiotic treatment enhanced pB-ALL development in Pax5+/- predisposed (63% vs. 22%) but not in wildtype mice (0%). This finding was observed in the presence but also -to a lesser extent- in the absence of a natural, infectious environment (48%). The composition of the gut microbiome constitutes a biomarker signature and allows to identify specifically those Pax5+/- mice that developed leukemia. This indicates that the gut microbiome can be used to identify carriers at risk to develop leukemia and to reduce this risk by early-life interventions.

2019-10-30 | GSE139547 | GEO

mice cecum and faeces gut metagenome

Project description:mice cecum and faeces gut metagenome Raw sequence reads

| PRJNA686640 | ENA

gut microbiome

Project description:gut microbiome Raw sequence reads

| PRJNA608183 | ENA

gut microbiome

Project description:gut microbiome Raw sequence reads

| PRJNA1003964 | ENA