Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

NHLBI TOPMed: Diabetes Heart Study African American Coronary Artery Calcification (AA CAC)

ABSTRACT: NHLBI TOPMed: Diabetes Heart Study African American Coronary Artery Calcification (AA CAC)

PROVIDER: PRJNA394787 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Integrative DNA, RNA and protein evidence connects TREML4 to coronary artery calcification

Project description:Peripheral blood RNA-Seq from human coronary artery calcification cases and controls; Coronary artery calcification (CAC) is a heritable and definitive morphologic marker of atherosclerosis that strongly predicts risk for future cardiovascular events. To search for genes involved in CAC, we used an integrative transcriptomic, genomic, and protein expression strategy using next-generation DNA sequencing in the discovery phase with follow-up studies using traditional molecular biology and histopathology techniques. Eight cases and eight controls (matched for gender, age and ancestry); RNA sequencing of peripheral blood from a discovery set of eight CAC cases and eight matched controls was used to identify dysregulated genes, which were validated using the NanoString® and Affymetrix GeneChip® Human Exon ST Array platforms. The median CAC scores for cases in the screening and validation sets were 1531.5 and 668.5, respectively, while all controls had a score of zero.

2014-06-10 | E-GEOD-58150 | biostudies-arrayexpress

Integrative DNA, RNA and protein evidence connects TREML4 to coronary artery calcification

2014-06-10 | GSE58150 | GEO

Homo sapiens

Project description:NHLBI TOPMed: Diabetes Heart Study African American Coronary Artery Calcification (AA CAC)

| PRJNA394788 | ENA

Comprehensive identification of RNA transcripts and construction of RNA networks in coronary arterial calcification

Project description:Here, we report a comprehensive analysis of dysregulated mRNAs, lncRNAs, miRNAs and circRNAs in peripheral blood of CAC patients with high-throughput RNA sequencing. We mapped about 50 million sequence reads per sample to the human genome. GSEA analysis showed that these dysregulated RNAs correlate with several critical biological processes such as RNA modification, and RNA metabolism. RT-qPCR (SYBR Green assays) with more clinical CAC samples were used for the validation of some dysregulated RNAs. We have also constructed the co-expression network between lncRNA and mRNA, and established the circRNA-miRNA-mRNA in CAC based on this data. This study provides valuable insights to understand the RNA involvement and regulation in CAC, assisting future CAC investigations.

2022-07-01 | GSE194304 | GEO

NHLBI TOPMed: Partners HealthCare Biobank

Project description:NHLBI TOPMed: Partners HealthCare Biobank

| PRJNA300701 | ENA

Project description:aa

| PRJEB29549 | ENA

NHLBI TOPMed: CARDIA (Coronary Artery Risk Development in Young Adults)

Project description:NHLBI TOPMed: CARDIA (Coronary Artery Risk Development in Young Adults)

| PRJNA474060 | ENA

NHLBI TOPMed: CARDIA (Coronary Artery Risk Development in Young Adults)

Project description:NHLBI TOPMed: CARDIA (Coronary Artery Risk Development in Young Adults)

| PRJNA474061 | ENA