Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and Glia [Human ATAC-Seq]

PROVIDER: PRJNA395916 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6956273_1.fastq.gz	Fastqsanger.gz
	SRR6956273_2.fastq.gz	Fastqsanger.gz
	SRR6956274_1.fastq.gz	Fastqsanger.gz
	SRR6956274_2.fastq.gz	Fastqsanger.gz
	SRR6956275_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and Glia

Project description:Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and Glia

| PRJNA395913 | ENA

Mus musculus

Project description:Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and Glia [Mouse ATAC-Seq]

| PRJNA395920 | ENA

Rattus norvegicus

Project description:Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and Glia [Rat ATAC-Seq]

| PRJNA395919 | ENA

Homo sapiens

Project description:Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and Glia [Human RNA-Seq]

| PRJNA395921 | ENA

Rattus norvegicus

Project description:Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and Glia [RAT RNA-Seq]

| PRJNA395918 | ENA

Mus musculus

Project description:Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and Glia [Mouse RNA-Seq]

| PRJNA395915 | ENA

Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and Glia [Mouse ATAC-Seq]

Project description:Determination of the molecular properties of genetically targeted cell types has led to fundamental insights into mouse brain function and dysfunction. Here, we report an efficient strategy for precise exploration of gene expression events in specific cell types in a broad range of species. We demonstrate that classically defined, homologous neuronal and glial cell types differ between rodent and human by the expression of hundreds of orthologous, cell specific genes. Confirmation that these genes are differentially active was obtained using epigenetic mapping, quantitative PCR, and immunofluorescence localization. Studies of sixteen human postmortem brains revealed cell-specific molecular responses to aging, and the induction of a shared, robust response to an unknown external event experienced by three donors. Our data establish a comprehensive approach for analysis of unique molecular events associated with specific circuits and cell types in a wide variety of human conditions.

2018-10-12 | GSE101914 | GEO