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Sus scrofa

ABSTRACT: RNA-seq analysis of sow mammary gland tissue from late pregnancy to farrowing.

PROVIDER: PRJNA396066 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5877110.fastq.gz	Fastqsanger.gz
	SRR5877111.fastq.gz	Fastqsanger.gz
	SRR5877112.fastq.gz	Fastqsanger.gz
	SRR5877113.fastq.gz	Fastqsanger.gz
	SRR5877114.fastq.gz	Fastqsanger.gz

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Sus scrofa

Project description:Expression data of porcine mammary glands from late pregnancy to peak lactation.

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RNA-sequencing of milk cells extracted from pre-partum secretions and longitudinally from mature human milk across the first year of lactation

Project description:Changes in mammary cell behavior mediating normal breast development during pregnancy and lactation are poorly understood due to limited availability of breast biopsies during this time. Human milk contains a hierarchy of cells including stem cells, mature milk producing cells (lactocytes) and myoepithelial cells. Here we non-invasively sampled the total epithelial cell population of the lactating mammary gland from mature HM collected from healthy mother/infant dyads during the first year postpartum, and explored temporal changes in the mammary cell transcriptome using RNA sequencing. Comparisons were done with mammary secretions from late pregnancy from the same women and with purchased resting mammary tissue. Distinct gene signatures were found for the different mammary developmental stages examined. Cell adhesion pathways were differentially regulated between the resting gland and pregnancy, whereas immune cell signaling and morphogenesis/cancer pathways differed between lactation and pregnancy or the resting gland, respectively. The transcriptome of lactation remained consistent in the first year postpartum in these successfully lactating women. The gene signatures characteristic of HM cells confirmed lactation genes previously reported in animal models and the HM fat globule. This study identifies key genes and molecular pathways undergoing controlled regulation as the mammary gland transitions from a quiescent into a functional organ, providing experimental targets for the molecular investigation of mammary gland pathologies.

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Transcription profiling of mouse mammary gland development

Project description:The mammary gland develops mainly postnatally, when during pregnancy the epithelium grows out into the mammary fat pad and forms a network of epithelial ducts. During pregnancy, these ducts branch and bud to form alveoli. These alveoli produce the milk during lactation. After 7 days of lactation, involution was induced by force weaning the pups. The newly formed epithelium undergoes apoptosis and is removed from the tissue by neighbouring epithelial cells. Tissue remodelling leads to a morphology resembling a gland of a pre-pregnant mouse. Microarray analysis was used to measure mRNA expression of genes during puberty, pregnancy, lactation and involution in a Balb/c mouse strain. Experiment Overall Design: Total RNA was extracted from the 4th (inguinal) gland after removal of the lymph node. Individual samples represent RNA from one gland of one mouse. Samples were taken in triplicate (i.e. three mice per triplicate) for 18 time points of development.

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Sus scrofa

Project description:Global transcriptome analysis of mammary tissue during fetal bud formation and growth in two pig breeds

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Transcriptome data used for Sus scrofa gene annotation

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Transcriptome profiling of nonlactating goat mammary glands.

Project description:The mammary gland redeveloped to the pre-pregnancy state during involution, which shows that the mammary cells have the characteristics of remodeling. The rapidity and degree of mammary gland involution are different between mice and dairy livestock (dairy cows and dairy goats). However, the molecular genetic mechanism of involution and remodeling of goat mammary gland has not yet been clarified. Therefore, this study carried out the RNA-sequencing of nonlactating mammary gland tissue of dairy goats in order to reveal the transcriptome characteristics of nonlactating mammary tissues and clarify the molecular genetic mechanism of mammary cell involution and remodeling.

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Sus scrofa

Project description:Transcriptome of sow ovary and porcine granulosa cells

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RNA-seq analysis of sow mammary gland tissue from late pregnancy to farrowing.

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