Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA396574 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR5885100.fastq.gz | Fastqsanger.gz | |||
| SRR5885110.fastq.gz | Fastqsanger.gz | |||
| SRR5885120.fastq.gz | Fastqsanger.gz | |||
| SRR5885130.fastq.gz | Fastqsanger.gz | |||
| SRR5885140.fastq.gz | Fastqsanger.gz |
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Project description:VHL loss is the most common genetic alteration event in ccRCC, but its effect on epigenetic landscape has not been elucidated previously. We describe the genome-wide cis-regulatory landscapes of VHL-deficient ccRCC tumors by comparing the epigenetic changes in terms of histone modifications (H3K27ac, H3K4me1, H3K4me3) with the transcriptomics profiles in 10 pairs of normal kidney and ccRCC tissues.
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