Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Eospalax fontanierii

ABSTRACT: Eospalax fontanierii overview

PROVIDER: PRJNA397938 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10988263_1.fastq.gz	Fastqsanger.gz
	SRR10988263_2.fastq.gz	Fastqsanger.gz
	SRR10988264_1.fastq.gz	Fastqsanger.gz
	SRR10988264_2.fastq.gz	Fastqsanger.gz
	SRR10988265_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 204

Similar Datasets

Eospalax fontanierii baileyi

Project description:Eospalax fontanierii baileyi(plateau zokor) Transcriptome

| PRJNA603638 | ENA

Eospalax fontanierii baileyi

Project description:Eospalax fontanierii baileyi Transcriptome or Gene expression

| PRJNA282349 | ENA

Eospalax fontanierii baileyi

Project description:Eospalax fontanierii baileyi Transcriptome or Gene expression

| PRJNA342079 | ENA

Eospalax fontanierii cansus

Project description:Eospalax fontanierii cansus Transcriptome or Gene expression

| PRJNA497961 | ENA

Eospalax fontanierii baileyi

Project description:Eospalax baileyi overview

| PRJNA214020 | ENA

Eospalax fontanierii baileyi strain:PZ1

Project description:Eospalax fontanierii baileyi strain:PZ1 Transcriptome or Gene expression

| PRJNA208780 | ENA

Eospalax fontanierii cansus strain:Bacteria | breed:Clone

Project description:Eospalax fontanierii cansus strain:Bacteria | breed:Clone Metagenome

| PRJNA397854 | ENA

Eospalax

Project description:Eospalax baileyi, Eospalax smith, Eospalax rufescens, Eospalax rothschildi, Eospalax cansus, Eospalax fontanierii Raw sequence reads

| PRJNA947478 | ENA

Eospalax rothschildi

Project description:Eospalax rothschildi overview

| PRJNA174705 | ENA

Transcriptome analysis of the liver of <i>Eospalax fontanierii</i> under hypoxia.

Project description:Hypoxia can induce cell damage, inflammation, carcinogenesis, and inhibit liver regeneration in non-adapted species. Because of their excellent hypoxia adaptation features, subterranean rodents have been widely studied to clarify the mechanism of hypoxia adaptation. Eospalax fontanierii, which is a subterranean rodent found in China, can survive for more than 10 h under 4% O2 without observable injury, while Sprague-Dawley rats can survive for less than 6 h under the same conditions. To explore the potential mechanism of hypoxia responses in E. fontanierii, we performed RNA-seq analysis of the liver in E. fontanierii exposed to different oxygen levels (6.5% 6h, 10.5% 44h, and 21%). Based on the bioinformatics analysis, 39,439 unigenes were assembled, and 56.78% unigenes were annotated using public databases (Nr, GO, Swiss-Prot, KEGG, and Pfam). In total, 725 differentially expressed genes (DEGs) were identified in the response to hypoxia; six with important functions were validated by qPCR. Those DEGs were mainly involved in processes related to lipid metabolism, steroid catabolism, glycolysis/gluconeogenesis, and the AMPK and PPAR signaling pathway. By analyzing the expression patterns of important genes related to energy associated metabolism under hypoxia, we found that fatty acid oxidation and gluconeogenesis were increased, while protein synthesis and fatty acid synthesis were decreased. Furthermore, the upregulated expression of specific genes with anti-apoptosis or anti-oxidation functions under hypoxia may contribute to the mechanism by which E. fontanierii tolerates hypoxia. Our results provide an understanding of the response to hypoxia in E. fontanierii, and have potential value for biomedical studies.

| S-EPMC8071069 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data