Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Two evolutionary developmental strategies for miRNA gene regulation in animal embryogenesis

ABSTRACT: Two evolutionary developmental strategies for miRNA gene regulation in animal embryogenesis

PROVIDER: PRJNA398371 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5935160.fastq.gz	Fastqsanger.gz
	SRR5935170.fastq.gz	Fastqsanger.gz
	SRR5935220.fastq.gz	Fastqsanger.gz
	SRR5935230.fastq.gz	Fastqsanger.gz
	SRR5935161.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 62

Similar Datasets

Two evolutionary developmental strategies for miRNA gene regulation in animal embryogenesis [DM_miRNA-seq]

Project description:miRNAs play essential roles in the mechanics of gene regulation, however, on an organismal-scale, the processes in they are deployed are not well understood. Here, we adopt an evolutionary developmental approach to study miRNA function by examining their expression throughout embryogenesis in both C. elegans and D. melanogaster. We find that, in both species, the miRNA complement of the transcriptome shifts in a punctuated fashion during the previously identified mid-developmental transition specifying two dominant modes of miRNA expression: an early and a late profile. Strikingly, we find that phylogenetically conserved miRNAs are expressed late, while early expressed miRNAs are inversely expressed with their targets suggesting strong target-inhibition. Our work exposes two distinct strategies of miRNA function comprising late-expressed physiological roles and early expressed repressive roles. In summary, the expression of miRNAs throughout embryogenesis in two species implicates their role in the canalization of cell-types during late phases of embryogenesis and repressing targets to lock-down misexpression.

2018-05-14 | GSE102681 | GEO

Two evolutionary developmental strategies for miRNA gene regulation in animal embryogenesis [CE_RNA-seq]

2018-05-14 | GSE102680 | GEO

Two evolutionary developmental strategies for miRNA gene regulation in animal embryogenesis [CE_miRNA-seq]

2018-05-14 | GSE102679 | GEO

Two evolutionary developmental strategies for miRNA gene regulation in animal embryogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-05-14 | GSE102682 | GEO

Caenorhabditis elegans

Project description:Two evolutionary developmental strategies for miRNA gene regulation in animal embryogenesis [CE_miRNA-seq]

| PRJNA398374 | ENA

Drosophila melanogaster

Project description:Two evolutionary developmental strategies for miRNA gene regulation in animal embryogenesis [DM_miRNA-seq]

| PRJNA398375 | ENA

Caenorhabditis elegans

Project description:Two evolutionary developmental strategies for miRNA gene regulation in animal embryogenesis [CE_RNA-seq]

| PRJNA398376 | ENA

Evolutionary dynamics of polyadenylation signals and their recognition strategies in protist

Project description:Evolutionary dynamics of polyadenylation signals and their recognition strategies in protist

| PRJNA1083039 | ENA

Two miRNAs are sufficient for C. elegans embryogenesis

Project description:The Microprocessor, composed of Drosha and Pasha/DGCR8, is necessary for the biogenesis of canonical microRNAs (miRNAs), and required for animal embryogenesis. However, the cause for this requirement is largely unknown. The Microprocessor may be required to produce one or few essential miRNAs, or alternatively, many individually non-essential miRNAs. Additionally, Drosha and Pasha/DGCR8 may be required for processing non-miRNA substrates. To distinguish between these possibilities, we developed a system in C. elegans to stringently deplete embryos from the Microprocessor and miRNAs. We show that the early embryonic arrest upon loss of the Microprocessor is rescued by the addition of two individual miRNAs from the miR-35 and miR-51 families, resulting in morphologically normal larvae. Thus, just two canonical miRNAs are sufficient for morphogenesis and organogenesis in C. elegans, and indicate that miRNA processing explains the essential requirement for the Microprocessor during embryogenesis.

2020-11-21 | GSE153233 | GEO

The developmental proteome of Drosophila melanogaster (embryogenesis)

Project description:Drosophila melanogaster is a well-studied genetic model organism with several large-scale transcriptome resources. Here we investigate 7,952 proteins during the fly life cycle from embryo to adult and also provide a high-resolution temporal time course proteome of 5,458 proteins during embryogenesis. We use our large scale data set to compare transcript/protein expression, uncovering examples of extreme differences between mRNA and protein abundance. In the embryogenesis proteome, the time delay in protein synthesis after transcript expression was determined. For some proteins, including the transcription factor lola, we monitor isoform specific expression levels during early fly development. Furthermore, we obtained firm evidence of 268 small proteins, which are hard to predict by bioinformatics. We observe peptides originating from non-coding regions of the genome and identified Cyp9f3psi as a protein-coding gene. As a powerful resource to the community, we additionally created an interactive web interface (http://www.butterlab.org) advancing the access to our data.

2017-04-07 | PXD005713 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data