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Genome-wide H3K4me3 and gene expression before and after methionine restriction in human cancer cells and mouse liver

ABSTRACT: Genome-wide H3K4me3 and gene expression before and after methionine restriction in human cancer cells and mouse liver

PROVIDER: PRJNA402050 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6014270.fastq.gz	Fastqsanger.gz
	SRR6014280.fastq.gz	Fastqsanger.gz
	SRR6014290.fastq.gz	Fastqsanger.gz
	SRR6014271.fastq.gz	Fastqsanger.gz
	SRR6014281.fastq.gz	Fastqsanger.gz

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Genome-wide map of H3K4me3 before and after methionine restriction in HCT116 cells.

Project description:The goals of this study were to compare the distribution of H3K4me3 before and after methionine restriction to understand how nutrient availability and alterations in methionine metabolism affect the epigenetic state and regulate gene transcription. To do this we performed ChIP-seq with an H3K4me3 antibody and RNA-seq using PolyA+ mRNA.

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Genome-wide H3K4me3 and gene expression before and after methionine restriction in human cancer cells and mouse liver

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Project description:Dietary methionine restriction (MR) has been shown to increase lifespan and decrease adiposity in rodents. This study was designed to examine the transcriptional effects of MR in metabolically relevant tissues. This experiment contains data from the liver. We analyzed MR-induced changes in gene expression using pooled RNA from liver of rats fed either a control purified amino acid diet (DL-methionine content of 0.86%) (CON) or a methionine-restricted diet (DL-methionine content of 0.172%)(MR). Rats were fed Purina rodent diet 5001 until 32 days of age and were then randomly assigned to be fed CON diet or MR diet for 20 months.

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Project description:Methionine, a sulfur-containing essential amino acid, is a key component of dietary proteins important for protein synthesis, sulfur metabolism, antioxidant defense, and signaling. However, the role of methionine in cancer progression remains inconclusive. On one hand, dietary methionine restriction is known to repress cancer growth and improve cancer therapy in xenografted tumors. On the other hand, methionine is also critical for T cell activation and differentiation, making it a potential tumor suppression nutrient by enhancing T cell-mediated anti-tumor immunity. Here we investigated the interaction between dietary methionine, immune cells, and cancer cells by allografting CT26.WT mouse colon carcinoma cells into immunocompetent Balb/c mice or immunodeficient NSG mice, then analyzed how dietary methionine contents affect their growth. Our results show that dietary methionine restriction suppresses tumor growth in immunodeficient NSG mice but promotes tumor progression in immunocompetentt Balb/c mice.

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