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CD95/Fas ligand mRNA is toxic to cells

ABSTRACT: CD95/Fas ligand mRNA is toxic to cells

PROVIDER: PRJNA403815 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5942450_1.fastq.gz	Fastqsanger.gz
	SRR5942450_2.fastq.gz	Fastqsanger.gz
	SRR5942441.fastq.gz	Fastqsanger.gz
	SRR5942451_1.fastq.gz	Fastqsanger.gz
	SRR5942451_2.fastq.gz	Fastqsanger.gz

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CD95/Fas ligand mRNA is toxic to cells through more than one mechanism

Project description:CD95/Fas ligand mRNA is toxic to cells through more than one mechanism

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CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-46]

Project description:CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-46]

| PRJNA907763 | ENA

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-63]

Project description:CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-63]

| PRJNA907764 | ENA

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-47]

Project description:CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-47]

| PRJNA907765 | ENA

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-64]

Project description:CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-64]

| PRJNA907767 | ENA

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-64]

Project description:Analysis of RISC bound short (s)RNAs in a HCT116 Drosha CD95 d.k.o. cell line expressing pLenti-CD95L and various CD95L mutant constructs.

2023-01-17 | GSE219225 | GEO

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [DISE-47]

Project description:Analysis of RISC bound short (s)RNAs in a HCT116 Drosha CD95 d.k.o. cell line expressing pLenti-CD95L and various CD95L mutant constructs.

2023-01-17 | GSE219223 | GEO

CD95/Fas ligand mRNA is toxic to cells.

Project description:CD95/Fas ligand binds to the death receptor CD95 to induce apoptosis in sensitive cells. We previously reported that CD95L mRNA is enriched in sequences that, when converted to si/shRNAs, kill all cancer cells by targeting critical survival genes (Putzbach et al., 2017). We now report expression of full-length CD95L mRNA itself is highly toxic to cells and induces a similar form of cell death. We demonstrate that small (s)RNAs derived from CD95L are loaded into the RNA induced silencing complex (RISC) which is required for the toxicity and processing of CD95L mRNA into sRNAs is independent of both Dicer and Drosha. We provide evidence that in addition to the CD95L transgene a number of endogenous protein coding genes involved in regulating protein translation, particularly under low miRNA conditions, can be processed to sRNAs and loaded into the RISC suggesting a new level of cell fate regulation involving RNAi.

| S-EPMC6191286 | biostudies-literature

CD95/Fas ligand mRNA is toxic to cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-09-20 | GSE103631 | GEO

CD95L mRNA is toxic to cells

Project description:>80% of a large number of tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death that is characterized by the simultaneous activation of multiple death pathways and preferentially affects transformed and cancer stem cells. We now show that these si/shRNAs kill cancer cells through canonical RNAi by targeting the 3’UTR of critical survival genes in a unique form of off-target effect. We also provide evidence showing that the full length CD95L mRNA is also toxic and produces small Ago-associated RNAs.

2018-09-21 | GSE114425 | GEO

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