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RNASeq analysis to detect any molecular changes in skin of Dlx4 ablated mice compared to Wild type littermates.

ABSTRACT: RNASeq analysis to detect any molecular changes in skin of Dlx4 ablated mice compared to Wild type littermates.

PROVIDER: PRJNA407807 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6049210.fastq.gz	Fastqsanger.gz
	SRR6049211.fastq.gz	Fastqsanger.gz
	SRR6049212.fastq.gz	Fastqsanger.gz
	SRR6049213.fastq.gz	Fastqsanger.gz
	SRR6049214.fastq.gz	Fastqsanger.gz

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RNASeq analysis to detect any molecular changes in skin of Dlx4 ablated mice compared to Wild type littermates.

Project description:DLX4 is a member of DLX family of mammalian homeobox genes and cis linked sister gene of Dlx3. Misexpression of Dlx4 is associated with tumorigenicity. However,Dlx4 role in epidermal development and homeostasis is not characterized. In this study, we compared Wild type (DLX4-WT) and DLX4 deficient (DLX4-KO) Skin transcriptomes.

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RNAseq of FACS Drd1 and Drd2 receptor expressing medium spiny neurons (direct and indirect medium spiny neurons) from 5-6 month Q175 Huntington's disease model mice, compared to WT littermates.

Project description:mRNAseq for baseline transcriptional profiling of D1 and D2 receptor-expressing medium spiny neurons from 5-6 month Q175 mice compared to WT littermates.

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Genome-wide analysis of Sox2-ablated optic cups compared with wild-type control optic cups at E16.5

Project description:To test the hypothesis that ablation of the SOX2 in the developing optic cup leads to expansion of peripheral optic cup signaling pathways, we screened whole-genome changes in gene expression in Sox2-mutant eyes compared with controls. Results confirm that ciliary epithelial (peripheral) identity is gained at the expense of neural retinal identity in Sox2-ablated optic cups.

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Immune response of germline-ablated P. pacificus exposed to S. marcescens

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RNA-seq of livers from glucagon receptor knock-out (GcgrKO) mice compared to wildtype littermates

Project description:RNA-seq of livers from glucagon receptor knock-out (GcgrKO) mice compared to wildtype littermates

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AMPK gamma3 knock-out and mutant (R225Q) transgenic mice compared to corresponding wild type littermates

Project description:AMPK gamma3 knock-out and mutant (R225Q) transgenic mice compared to corresponding wild type littermates

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RNAseq of FACS Drd1 and Drd2 receptor expressing medium spiny neurons (direct and indirect medium spiny neurons) from 5-6 month BACHD Huntington's disease model mice, compared to WT littermates

Project description:mRNAseq for baseline transcriptional profiling of D1 and D2 receptor-expressing medium spiny neurons from 5-6 month BACHD mice, compared to respective WT littermates. BACHD iSPN and dSPN RNAseq data has been described in "Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease"; Plotkin et al; 2014; PMID accession number 24991961.

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Proteomics data on LAST ablated material

Project description:Proteomics_LAST data for cell lysed ablated material on transmission geometry

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Gene expression profiles of heterozygous periphilin knockout mice compared to wt littermates

Project description:Periphilin is a protein which is involved in multiple processes in vivo, including terminal differentiation of keratinozytes as well as cell-cycle and cancer related functions. Here we generated mice with a targeted disruption of the periphilin-1 gene to explore its physiological role from an organismic perspective. In accordance with a ubiquitous expression of periphilin in the murine embryo, the homozygous deficiency of periphilin is lethal in early embryogenesis. We therefore characterized mice with a disruption of only one periphilin allele. As heterozygous periphilin knockout mice show no obvious histological alterations and have no apparent behavioural phenotypes, we compared whole transcriptome RNA expression profiles of total brain tissue of periphilin+/- knockout mice and wild type littermates for an in-depth analysis of heterozygous animals. In periphilin+/- knockout mice, 3 probe sets were indicative of significant differential expression (p ≤ 0.05, SLR ≥ 1 which is equivalent to 2 fold). Two of these probe sets (1438864_at and 1439170_at) refer to unannotated or unclassifiable genes. According to the NetAffx™ Analysis Center, the third probe set (1447831_s_at) is assigned to myotubularin related protein 7 (Mtmr7). The probe set, however, lies upstream of the Mtmr7 gene (Ensembl gene ENSMUSG00000039431), and its signal is therefore not representative for the Mtmr7 gene. Quantitative RT-PCR (qRT-PCR) analysis with a primer set specific for Mtmr7 confirmed that its expression is not altered in periphilin+/- knockout mice (relative expression compared to wild type: 0.924; p = 0.419). In summary, none of more than 45.000 covered transcripts is differentially expressed in periphilin+/- knockout mice in comparison to wild type littermates.

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