Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MiRNA and gene expression profiling in human thyroid carcinomas and non-neoplastic thyroids [RNA]

ABSTRACT: miRNA and gene expression profiling in human thyroid carcinomas and non-neoplastic thyroids [RNA]

PROVIDER: PRJNA407936 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

miRNA and gene expression profiling in human thyroid carcinomas and non-neoplastic thyroids [miRNA]

Project description:We performed miRNA and gene expression profiling in a series of 30 thyroid carcinomas and 6 non-neoplastic thyroids.

2020-09-30 | GSE103996 | GEO

miRNA and gene expression profiling in human thyroid carcinomas and non-neoplastic thyroids [RNA]

Project description:We performed miRNA and gene expression profiling in a series of 30 thyroid carcinomas and 6 non-neoplastic thyroids.

2020-09-30 | GSE104005 | GEO

miRNA and gene expression profiling in human thyroid carcinomas and non-neoplastic thyroids [miRNA]

Project description:miRNA and gene expression profiling in human thyroid carcinomas and non-neoplastic thyroids [miRNA]

| PRJNA407931 | ENA

miRNA and gene expression profiling in human thyroid carcinomas and non-neoplastic thyroids

Project description:miRNA and gene expression profiling in human thyroid carcinomas and non-neoplastic thyroids

| PRJNA407930 | ENA

Gene and miRNA expression in radioiodine refractory and avid papillary thyroid carcinomas (miRNA expresseion dataset)

Project description:We performed gene and miRNA expression profiling in a series of 39 papillary thyroid carcinomas (PTCs) and 13 matched non-neoplastic thyroids derived from PTC patients with metastatic disease and submitted to radioiodine (RAI) treatment.

2021-05-17 | GSE151180 | GEO

Gene and miRNA expression in radioiodine refractory and avid papillary thyroid carcinomas (gene expression dataset)

2020-11-24 | GSE151179 | GEO

Normal thyrocytes vs papillary vs anaplastic thyroid carcinomas

Project description:We profiled the gene expression of 11 anaplastic thyroid carcinomas (ATC), 49 papillary thyroid carcinomas (PTC) and 45 normal thyroids (N)

2012-11-09 | GSE33630 | GEO

Transcritional profiling in 30 follicular cell derived thyroid cancers

Project description:We established transcriptional profiles by microarray in a small series of follicular cell derived thyroid cancers collected at our Institute. This series comprises 27 papillary thyroid carcinomas (PTCs), the most common type of thyroid cancer, and 3 poorly differentiated thyroid carcinomas (PDTCs). Two patient matched non-neoplastic thyroids are also included as controls.

2024-07-27 | E-MTAB-13222 | biostudies-arrayexpress

Normal thyrocytes vs papillary vs anaplastic thyroid carcinomas

Project description:We profiled the gene expression of 11 anaplastic thyroid carcinomas (ATC), 49 papillary thyroid carcinomas (PTC) and 45 normal thyroids (N) We hibridized a series of anaplastic thyroid carcinomas (ATC) and papillary thyroid carcinomas (PTC) onto Affymetrix U133 Plus 2.0 arrays. ATCs were obtained from different hospitals in France and Belgium. Paired RNA samples of PTCs and non-tumoral thyroid tissues were obtained from Ukraine via the Chernobyl Tissue Bank (www.chernobyltissuebank.com). Diagnoses were confirmed by the members of the International Pathology Panel of the Chernobyl Tissue Bank.

2012-11-09 | E-GEOD-33630 | biostudies-arrayexpress

PIAS2b dsRNAi repression kills by mitotic catastrophe anaplastic thyroid and non-thyroid carcinomas, but not normal thyroid or differentiated carcinomas

Project description:The E3 SUMO ligase PIAS2 is expressed at high levels in differentiated papillary thyroid carcinomas but at low levels in anaplastic thyroid carcinomas (ATC), an undifferentiated cancer with very high mortality. Double-stranded RNA–directed RNA interference (dsRNAi) targeting the PIAS2 isoform beta (PIAS2b) inhibits growth of ATC cell lines and patient primary cultures in vitro and orthotopic patient-derived xenografts (oPDX) in vivo, but not of thyroid cell lines or non-anaplastic primary thyroid cultures (differentiated carcinoma, benign lesions, or normal). PIAS2b-dsRNAi also has an anti-cancer effect on other anaplastic human cancers (pancreas, lung, and gastric). Mechanistically, PIAS2b is required for proper mitotic spindle and centrosome assembly, and it is a dosage-sensitive protein in ATC. Strikingly, PIAS2b-dsRNAi induces mitotic catastrophe at prophase. High-throughput proteomics revealed the proteasome (PSMC5) and spindle cytoskeleton as direct targets of PIAS2b SUMOylation at mitotic initiation. PIAS2b-dsRNAi is a promising therapy for ATC and other aggressive anaplastic cancers.

2024-04-08 | PXD044110 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data