Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cell type-specific dysregulation of ERK signaling impairs synaptic plasticity and memory in a mouse model of Noonan syndrome

ABSTRACT: Cell type-specific dysregulation of ERK signaling impairs synaptic plasticity and memory in a mouse model of Noonan syndrome

PROVIDER: PRJNA408228 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6056684_1.fastq.gz	Fastqsanger.gz
	SRR6056684_2.fastq.gz	Fastqsanger.gz
	SRR6056685_1.fastq.gz	Fastqsanger.gz
	SRR6056685_2.fastq.gz	Fastqsanger.gz
	SRR6056686_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Cell type-specific dysregulation of ERK signaling impairs synaptic plasticity and memory in a mouse model of Noonan syndrome

Project description:We report transcriptome data from excitatory and inhibitory neurons of mouse brain.

2019-04-17 | GSE104089 | GEO

Transcriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders

Project description:Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs) from four members of a family in which a frame-shift mutation of Disrupted-in-schizophrenia-1 (DISC1) co-segregated with psychiatric disorders and further produced different isogenic iPSC lines via genetic editing. We showed that mutant DISC1 causes synaptic vesicle release deficits in iPSC-derived forebrain neurons. Mechanistically, mutant DISC1 dysregulates the expression of many genes related to synapses and psychiatric disorders and depletes wild-type DISC1 and the NCoR1 transcription co-repressor complex. Furthermore, mechanism-guided pharmacological inhibition of phosphodiesterases rescues synaptic defects in mutant neurons. Our study uncovers a novel gain-of-function mechanism through which the psychiatric disorder-relevant mutation affects synaptic functions via transcriptional dysregulation and provides insight into the molecular and synaptic etiopathology of psychiatric disorders. Two patient derived iPSC lines carrying heterozygous 4bp deletion in DISC1 gene and 1 related control were analyzed in biological triplicate

2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress

miR-101a-3p impairs synaptic plasticity and contributes to synucleinopathy

Project description:miR-101a-3p impairs synaptic plasticity and contributes to synucleinopathy

| PRJNA803028 | ENA

Early life stress in fathers impairs synaptic plasticity in the offspring - brain collected at rest

Project description:We show that traumatic stress experienced by males in early postnatal life impairs memory in their offspring, blocks long-term potentiation (LTP) and favors long-term depression (LTD). These effects are accompanied by suppression of key molecular pathways involved in neuronal plasticity both at rest and after acute stress. Male mice were exposed to chronic traumatic stress in early postnatal life and were later bred to naM-CM-/ve females to produce second-generation offspring. Memory performance was evaluated in the offspring, and synaptic plasticity was examined in the hippocampus and the amygdala, brain areas important for memory formation. The two groups tested were 1: offspring of fathers which were stressed (MSUS - maternal separation unpredictable stress) and 2: offspring of non-stressed fathers (control). Genome-wide gene expression in hippocampus of these two groups was assessed at rest (this study) and after acute stress.

2014-07-01 | E-GEOD-47846 | biostudies-arrayexpress

Transcriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders

2014-08-01 | GSE57821 | GEO

Early life stress in fathers impairs synaptic plasticity in the offspring - brain collected after acute swim stress

2014-07-01 | E-GEOD-47847 | biostudies-arrayexpress

AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons

Project description:AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons

| PRJNA1043558 | ENA

CRISPR repair in a preclinical model of Noonan syndrome associated cardiomyopathy I

Project description:We profiled RNA expression in human iPSC-derived cardiomyocytes from patients with LZTR1-associated Noonan syndrome

2020-08-25 | GSE145348 | GEO

CRISPR repair in a preclinical model of Noonan syndrome associated cardiomyopathy II