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MiRNA expression profiling in cholangiocarcinoma (CCA) cells treated with TGF-b

ABSTRACT: MiRNA expression profiling in cholangiocarcinoma (CCA) cells treated with TGF-b

PROVIDER: PRJNA413372 | ENA |

REPOSITORIES: ENA

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MiRNA expression profiling in cholangiocarcinoma (CCA) cells treated with TGF-b

Project description:Expression profiling of 2555 miRNAs was performed using microarray. Of these, 451 miRNAs expressed in CCA cells. Microarray identified 17 miRNAs that were increased by > 1.5-fold and 56 miRNAs that were decreased by < 0.67-fold in CCA cells treated with TGF-β.

2018-04-18 | GSE104629 | GEO

Serum exosome miRNA expression profile in patients with cholangiocarcinoma(CCA) and common bile duct stones(CBDS)

Project description:Cholangiocarcinoma (CCA) is a type of highly aggressive cancer arising from the biliary system. Through serum exosome miRNA sequencing, we screened out the differentially expressed miRNA in patients with cholangiocarcinoma(CCA) and common bile duct stones(CBDS).

2022-10-20 | GSE215448 | GEO

FOSL1 transcriptome in cholangiocarcinoma (CCA) cells

Project description:FOSL1 transcriptome in cholangiocarcinoma (CCA) cells

| PRJNA648046 | ENA

FOSL1 target genes in cholangiocarcinoma (CCA) cells

Project description:FOSL1 target genes in cholangiocarcinoma (CCA) cells

| PRJNA648044 | ENA

FOSL1 target genes in cholangiocarcinoma (CCA) cells

Project description:We report the characterization of FOSL1-bound transcriptional targets in CCA cells. Target genes include different RNA species involving protein coding genes, lncRNA, miRNA and others

2023-07-22 | GSE154953 | GEO

MiRNA expression profiling in cholangiocarcinoma (CCA) cells compared to non-malignant human cholangiocyte

Project description:MiRNA expression profiling in cholangiocarcinoma (CCA) cells compared to non-malignant human cholangiocyte

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Cholangiocarcinoma cell line (CCA cell line KKU-213A) treated in lactic acidosis condition

Project description:Cholangiocarcinoma cell line (CCA cell line KKU-213A) treated in lactic acidosis condition

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Integrative Transcriptomic Profiling reveals Hepatic Stem-like Phenotype and Interplay of EMT and miR-200c in Intrahepatic Cholangiocarcinoma [miRNA]

Project description:We compared transcriptomic profiles of ICC tumor specimens to hepatocellular carcinoma (HCC) specimens using Affymetrix mRNA array and the miRNA array platforms to search for unique gene signatures linked to patient prognosis. ICC and HCC share common stem-like molecular characteristics and stem-like tumor features associated with poor prognosis. Gene expression profiling of 16 intrahepatic cholangiocarcinoma (ICC), 7 mixed type of combined hepatocellular cholangiocarcinoma (CHC), 2 Hepatic adenoma, 3 focal nodular hyperplasia (FNH), 5 non-tumor liver tissues, and 2 CCA cell lines were performed.

2012-09-28 | E-GEOD-32957 | biostudies-arrayexpress

The miRNAome of O. viverrini induced cholangiocarcinoma by microarray:

Project description:Cholangiocarcinoma is the second most common primary hepatic malignancy worldwide, with intrahepatic cholangiocarcinoma (ICC) a particularly significant public health problem in Southeast Asia, due to its strong association with the food-borne parasite Opisthorchis viverrini (OV). This manuscript represents the first comprehensive miRNA expression profiling by microarray of the three most common histological grades of OV-induced ICC: moderately differentiated, papillary, and well differentiated tumor tissue. No cohort of miRNAs emerged as commonly dysregulated among these histological grades of OV-induced ICC. Instead, each histological grade of ICC tissue showed a distinct miRNA profile. Moderately differentiated tumor tissue showed both the greatest number and the highest magnitude of miRNA dysregulation, followed by papillary ICC tumor tissue, and differentiated ICC tumor tissue. When ICC tumor tissue was compared to adjacent non-tumor tissue, a remarkable similarity in miRNA dysregulation was observed between these samples, indicative of intrahepatic metastasis. These findings indicate the possibility of determining the histological grade of ICC by profiling miRNA dysregulation, which not only would greatly enhance the molecular diagnosis of ICC, but could even lead to the personalized the treatment for ICC by the early classification of histological grade. A total of 46 unique liver tissue samples were analyzed on Agilent human miRNA microarray (miRBase Release 16.0). Of the 46 samples, 13 are from non-cancer healthy patients with gastric bypass surgery. The rest of 33 samples are CCA tumor tissue samples and their paired adjacent normal/necrotic tissue: 12 from well differentiated CCA, 17 from papillary CCA, 4 from moderately differentiated CCA.

2014-07-17 | E-GEOD-53992 | biostudies-arrayexpress

TGF-beta signature in cholangiocarcinoma cell lines

Project description:The aim of the study was to characterize the transcriptional profiles of two cholangiocarcinoma cell lines (HuCCT1 and Huh28) after a treatment with Transforming Growth Factor beta (TGF-beta).

2018-02-01 | GSE102109 | GEO

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