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Zinc transporter ZIP8 (SLC39A8) overexpression effect on primary mouse articular chondrocytes

ABSTRACT: Zinc transporter ZIP8 (SLC39A8) overexpression effect on primary mouse articular chondrocytes

PROVIDER: PRJNA413833 | ENA |

REPOSITORIES: ENA

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Zinc transporter ZIP8 (SLC39A8) overexpression effect on primary mouse articular chondrocytes

Project description:Gene expression profiling of primary mouse articular chondrocyte infected with recombinant adenovirus expressing the zinc transporter ZIP8 (SLC39A8) protein. In this study, we have attempted to explore the effects of ZIP8 overexpression on mouse transcriptome and have identified numerous genes which are involved in osteoarthritis pathogenesis.

2017-10-10 | GSE104795 | GEO

RNA-seq data from mouse articular chondrocytes

Project description:To understand the effect of semaphorin 4D on articular chondrocytes, articular chondrocytes were stimulated with semaphorin 4D. Total RNA was analyzed by RNA-seq.

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Genes regulated by TGF-beta in bovine articular chondrocytes

Project description:Bovine articular chondrocytes were grown in micromass culture and were either untreated or treated with 5 ng TGF-b1/ml for 8 hours to identify genes regulated by TGF-b. Six total samples were analyzed. Three biological replicates of untreated bovine articular chondrocytes grown in micromass culture and three biological replicates of bovine articular chondrocytes grown in micromass culture and treated with 5ng TGF-b1/ ml for 8 hours.

2011-09-30 | E-GEOD-29233 | biostudies-arrayexpress

RNA-seq analysis of Slc39a8(neo/neo) versus wild-type mice: yolk sac, placenta and fetal liver, kidney, lung, heart and cerebellum

Project description:Slc39a8 encodes ZIP8, a ubiquitous divalent cation/bicarbonate symporter expressed in pluripotent mouse embryonic stem cell; ZIP8 influxes Zn2+, Mn2+ and Fe2+. Slc39a8(neo/neo) knockdown mice globally exhibit 10-15% of wild-type ZIP8 mRNA and protein levels, and show a pleiotropic phenotype of stunted growth, neonatal lethality, multi-organ dysmorphogenesis, and dysregulated hematopoiesis manifested as severe anemia. Herein we performed transcriptomics of GD13.5 yolk sac and placenta, and GD16.5 liver, kidney, lung, heart and cerebellum, comparing Slc39a8(neo/neo) with wild-type. Meta-data analysis of differentially-expressed genes revealed 29 unique genes from all tissues –– having enriched GO categories associated with hematopoiesis and hypoxia and KEGG categories of complement, response to infection, and the coagulation cascade –– consistent with dysregulated hematopoietic stem cell fate. Based on transcription factor (TF) profiles in the JASPAR database, and searching for TF-binding sites enriched by Pscan, numerous genes encoding zinc-finger TFs and associated with hematopoietic stem cell functions were identified. We conclude that, in this mouse model, deficient ZIP8-mediated Zn2+ transport affects zinc-finger (e.g. GATA proteins) and other transcription-factors (e.g. TAL1) predominantly in yolk sac, strongly supporting the observed dysmorphogenesis and anemia phenotype.

2018-07-01 | GSE111080 | GEO

Comparison between articular chondrocytes and mesenchymal stromal cells for the production of articular chondrocyte implants

Project description:Focal lesions of articular cartilage give rise to pain and reduced joint function and may, if left untreated, lead to osteoarthritis. Implantation of in vitro generated, scaffold-free autologous cartilage discs may represent the best treatment option. Here we compare articular chondrocytes (ACs) and bone marrow-derived mesenchymal stromal cells (MSCs) for their ability to make scaffold-free cartilage discs.

2023-02-07 | PXD029434 | Pride

Rip3 effect on mouse articular chondrocytes

Project description:Rip3 effect on mouse articular chondrocytes

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Nox4 effect on mouse articular chondrocytes

Project description:Nox4 effect on mouse articular chondrocytes

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ActivinA effect on mouse articular chondrocytes

Project description:ActivinA effect on mouse articular chondrocytes

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Nox4 effect on mouse articular chondrocytes

Project description:Gene expression profiling of mouse articular chondrocytes infected with Ad-C or Ad-Nox4 In this study, we have attempted to explore the effects of Nox4 and have identified numerous genes which are involved in osteoarthritis pathogenesis.

2022-03-01 | GSE146272 | GEO

Rip3 effect on mouse articular chondrocytes

Project description:Gene expression profiling of mouse articular chondrocytes infected with Ad-C or Ad-Rip3 In this study, we have attempted to explore the effects of Rip3 and have identified numerous genes which are involved in osteoarthritis pathogenesis.

2022-07-01 | GSE154669 | GEO

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